ArticleJournal of the American Heart Association2026
Alternative Preservation Strategies of Donation After Circulatory Death Hearts: Effect of Cold Ischemia Time Before Normothermic Machine Perfusion.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Ex vivo heart perfusion induces time dependent inflammatory activation in human donor hearts.NPJ cardiovascular health · 2026Article
Corrections and comments
- Update of
Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDonation after circulatory death (DCD) offers a promising strategy to expand the donor pool by 20% to 30%. However, DCD heart grafts experience warm ischemia injury, making effective graft viability assessment before transplantation prudent. Current methods for assessing DCD hearts are impacted by either ethical concerns and regional limitations (thoracoabdominal normothermic regional perfusion) or the need for significant resources, expertise, and equipment, with limitations in functional assessment (direct procurement and reperfusion, via the Organ Care System by TransMedics). This study explores an alternative preservation approach using controlled hypothermia followed by normothermic machine perfusion for graft evaluation.
methodsDCD grafts were procured from porcine donors after 19 minutes of functional warm ischemia. Hearts were preserved using controlled hypothermic static storage at 4 °C to 8 °C for up to 7 hours, followed by reanimation with normothermic machine perfusion. Graft viability was evaluated using a novel ex vivo cardiac loading method. Outcomes were compared with DCD grafts reperfused immediately after procurement.
resultsNo significant functional, biochemical, or proteomic differences were observed between DCD cardiac grafts preserved via controlled hypothermia for up to 7 hours and those reperfused immediately after procurement.
conclusionsControlled hypothermia may be a viable alternative to current DCD preservation methods, eliminating ethical concerns of thoracoabdominal normothermic regional perfusion and reducing logistical complexity and costs associated with direct procurement and reperfusion. These findings provide a foundation for a potential shift in DCD heart preservation practices, offering a more effective and cost-efficient approach to expand the donor pool and improve transplantation outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.