Lysosome-Targeted Squaramide Anion Transporters.

Elba Feo, Edward York, Anthony Thai, William G Ryder, Daniel A McNaughton, Philip A Gale

Abstract read

In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elba FeoSchool of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia.

Edward YorkSchool of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia.

Anthony ThaiSchool of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia.

William G RyderSchool of Chemistry, University of Sydney, Sydney, New South Wales, Australia.

Daniel A McNaughtonMonash Institute of Pharmaceutical Science, Monash University, Parkville, Victoria, Australia.

Philip A GaleSchool of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0001-9751-4910

Funding

the University of GroningenUTS

6 · The paper itself

Abstract

Targeting anion transporters to specific organelles has previously been shown to be an effective strategy to enhance their cytotoxicities against cancerous cell lines. In this work a new family of squaramide anion transporters appended with two different lysosome targeting groups via a 1,4-substituted benzene spacer were synthesised. Cell viability studies showed that the transporters containing the N,N-dimethylamine targeting group exhibited the greatest cytotoxic effects despite possessing lower transport activities than the non-targeted control compounds and those containing the morpholine targeting group. Subcellular localisation studies using anthracene-labelled squaramides found that both targeting motifs successfully directed compounds to the lysosome, but the morpholine-containing motif accumulated to a lesser extent.

Indexed as

AnionsLysosomesQuinineAnthracenesCell Line, TumorCell SurvivalHumansMorpholinesAnionsAnthracenesmorpholineMorpholinesQuininesquaramideanion bindinganion transportlysosome‐targetingsquaramidessupramolecular chemistry

Identifiers

PMID42261900

DOI10.1002/chem.71243

PMCPMC13602887

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.