Evidence map›Paper›PMID 42261876›Full record

Trial reportAnnals of medicine2026

Oro-esophageal feeding for tracheostomized patients with severe traumatic brain injury: a randomized controlled trial.

Dandan Lv, Hongyan Liu, Jing Zhao, Yang Liu, Qianqian Li, Xing'na Zhao, Liugen Wang, Xi Zeng, Yu Ding

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06328985 (A Randomized Controlled Study to Explore the Effect of Different Feeding in Traumatic Brain Injury Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06328985 nacompletednot on this map

A Randomized Controlled Study to Explore the Effect of Different Feeding in Traumatic Brain Injury Patients

TypeinterventionalSponsorZeng XiRan2024 to 2025Enrolled98ConditionsTraumatic Brain InjuryArmsRehabilitation therapy, Intermittent Oro-esophageal Tube Feeding, Nasogastric tube feeding
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dandan LvDepartment of Respiratory and Critical Care Medicine, The Second Medica Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Hongyan LiuDepartment of Respiratory and Critical Care Medicine, The Second Medica Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Jing ZhaoDepartment of Respiratory and Critical Care Medicine, The Second Medica Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Yang LiuDepartment of Neurology, The Second Medica Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Qianqian LiDepartment of Neurology, The First Medica Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Xing'na ZhaoDysphagia Research Institute, Zhengzhou University, Zhengzhou, China.
Liugen WangDysphagia Research Institute, Zhengzhou University, Zhengzhou, China.
Xi ZengDysphagia Research Institute, Zhengzhou University, Zhengzhou, China.
Yu DingDepartment of Neurology, The Second Medica Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study reports the clinical effects of intermittent oro-esophageal tube feeding (IOE) versus nasogastric tube feeding (NGT) on nutritional status, aspiration pneumonia, decannulation, and level of consciousness in tracheostomized patients with severe traumatic brain injury (sTBI).

methodsA randomized controlled trial was conducted between March 2024 and October 2025 in China and included tracheostomized patients with sTBI. Participants were randomized 1:1 to the intervention and control groups for 28-day interventions. IOE or NGT was used for nutritional supports, respectively. The primary outcome was nutritional status, including hemoglobin, albumin, prealbumin and body mass index. The secondary outcomes included aspiration pneumonia, decannulation, and level of consciousness assessed using the Glasgow Coma Scale (GCS). Generalized linear mixed-effects models, generalized estimating equations, and Cox regression were used for data analyze.

resultsA total of 104 participants were included in the analysis. After intervention, significant interaction effects were observed in hemoglobin (

conclusionsIn tracheostomized patients with sTBI who received routine treatment, IOE is more conducive to decannulation and the improvement in nutritional status, aspiration pneumonia, and level of consciousness than NGT. CLINICAL

trial registrationProspectively registered at ClinicalTrials.gov (NCT06328985, 03/18/2024, clinicaltrials.gov/study/NCT06328985).

Indexed as

Brain Injuries, TraumaticEnteral NutritionIntubation, GastrointestinalPneumonia, AspirationTracheostomyAdultChinaFemaleGlasgow Coma ScaleHumansMaleMiddle AgedNutritional StatusTracheostomy DecannulationTreatment Outcomedysphagiaintermittent oro-esophageal tube feedingnasogastric tubeNGTrehabilitationtracheostomyTraumatic brain injury

Identifiers

PMID42261876
PMCPMC13250868

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.