ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Endogenously generated Dutch-type Aβ non-fibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation.
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Transcriptomic Challenges We Faced with Animal Models for Neurological Disorders.Current issues in molecular biology · 2026Review
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Authors and funding
29 authors.
Emilie L CastranioDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Merina VargheseGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, Rhode Island, USA.
Elentina K ArgyrousiDepartment of Pathology and Cell Biology, Department of Medicine, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Kuldeep TripathiDepartment of Chemistry, Bar-Ilan University, Ramat Gan, Israel.
Yong HuangDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Akiko AsadaTokyo Metropolitan University, Hachioji, Japan.ORCID https://orcid.org/0009-0006-8574-4640
Linda SöderbergBioArctic, Stockholm, Sweden.
Erin BresnahanNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
David LernerNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Francesca GarrettiNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hong ZhangDepartment of Pathology and Cell Biology, Department of Medicine, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Jonathan van de LooDepartment of Pathology and Cell Biology, Department of Medicine, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Cheryl D StimpsonDepartment of Pathology, Uniformed Services University of Health Sciences, Bethesda, Maryland, USA.
Ronan TaltyGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, Rhode Island, USA.
Charles GlabeDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA.
Efrat LevyCenter for Dementia Research, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA, and Departments of Psychiatry, Biochemistry & Molecular Pharmacology, and Neuroscience, New York University Grossman School of Medicine, NYU Langone Medical Center, New York, New York, USA.
Minghui WangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Marjan IlkovDepartment of Medical Imaging and Radiation Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Toshiharu SuzukiTokyo Metropolitan University, Hachioji, Japan.
Kanae AndoTokyo Metropolitan University, Hachioji, Japan.ORCID https://orcid.org/0000-0002-3956-276X
Bin ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lars LannfeltBioArctic, Stockholm, Sweden.
Brigitte GuérinDepartment of Medical Imaging and Radiation Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
William D LubellDepartment of Chemistry, Université de Montreal, Montreal, Quebec, Canada.
Shai RahimipourDepartment of Chemistry, Bar-Ilan University, Ramat Gan, Israel.
Dara L DicksteinNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sam GandyDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ottavio ArancioDepartment of Pathology and Cell Biology, Department of Medicine, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Michelle E EhrlichDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0001-9397-686X
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MResearch Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Mary Sano · 2020 to 2026
$31.0MIntegrative Network Biology Approaches to Identify, Characterize and Validate Molecular Subtypes in Alzheimer's DiseaseU01AG046170 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WANG, MINGHUI, ZHANG, BIN · 2013 to 2022
$26.0MSYSTEMATIC DRUG REPURPOSING TARGETING IMMUNE ACTIVATION NETWORKS IN ALZHEIMER'S DISEASE (AD)RF1AG059319 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, GANDY, SAMUEL E. · 2018 to 2018
$4.2MUse of iPSC systems to define roles of microglial TREM2/DAP12 and CR3/DAP12 complexes and their genetic variants in specifying risk for late onset sporadic Alzheimer's diseaseR01AG061894 · NIA · NEW YORK STEM CELL FOUNDATION · PI FOSSATI, VALENTINA, GANDY, SAMUEL E. · 2018 to 2022
$4.2MIntegrated understanding of complex viral network biology in Alzheimer's DiseaseRF1AG058469 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, GANDY, SAMUEL E. · 2019 to 2019
$4.1MConformational polymorphisms of amyloid in AD and immunological biomarkers and therapeuticsRF1AG056507 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI GLABE, CHARLES G. · 2018 to 2019
$3.6MTowards a comprehensive signaling pathway map of parahippocampal vulnerability in Alzheimers DiseaseRF1AG057440 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAROUTUNIAN, VAHRAM, NOGGLE, SCOTT ALLEN · 2017 to 2017
$3.5MA new perspective on the role of extracellular vesicles in Alzheimer's diseaseRF1AG086510 · NIA · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI D'ACUNZO, PASQUALE, LEVY, EFRAT · 2024 to 2024
$2.4MThe Role of SUMOylation in Tau-Mediated PathologyR01NS110024 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARANCIO, OTTAVIO · 2019 to 2023
$2.0MDissect regulation of glial nets surrounding amyloid plaques in Alzheimer's diseaseRF1AG077828 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRIEDEL, ROLAND HORST, WANG, MINGHUI · 2022 to 2022
$1.8MSystematic identification of genetic modifiers of dysfunctional neuronal networks in Alzheimer's diseaseR21AG077168 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LI, AIQUN, WANG, MINGHUI · 2022 to 2022
$465kAlzheimer's Association AARG-22-928419Alzheimer's Association NIRG-12-242386American Federation for Aging ResearchCure Alzheimer's FundI M Ertegun Project for Cognitive Health ExtensionJapan Agency for Medical Research and Development JP24wm0625509Japan Society for the Promotion of Science (B) 24K02860NCI NIH HHS P30 CA008748NIA NIH HHS P30 AG066514NIA NIH HHS R21 AG077168NIA NIH HHS U01 AG046170NIH HHS AG056732NIH HHS F32AG077900NIH HHS P30 AG066514NIH HHS R01AG061894NIH HHS R01NS110024NIH HHS R21AG077168NIH HHS RF1AG056507NIH HHS RF1AG057440NIH HHS RF1AG058469NIH HHS RF1AG059319NIH HHS RF1AG077828NIH HHS RF1AG086510NIH HHS U01AG046170
Abstract
backgroundAPP
methodsWe assessed the physiological, transcriptomic, ultrastructural, histological, and metabolic changes associated with the accumulation of NFA of Dutch Aβ in brains of APP
resultsAging-related accumulation of NFA-Aβ in APP DISCUSSION: Accumulation of NFA-Aβ alters neuronal metabolism but does not activate inflammation. Depletion of all forms of Aβ may be required to eliminate Aβ toxicity with anti-amyloid antibodies.
Indexed as
Amyloid beta-PeptidesAmyloid beta-Protein PrecursorPresynaptic TerminalsSynaptic TransmissionAgingAlzheimer DiseaseAnimalsBrainInflammationMiceMice, TransgenicNeuronsAmyloid beta-PeptidesAmyloid beta-Protein Precursoramyloidosiselectron microscopyelectrophysiologyoligomerproteinopathyprotofibrilsynapsetranscriptomics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.