Evidence map›Paper›PMID 42261690›Full record

ArticleJournal of natural products2026

Discovery of Ribosomally Synthesized and Post-translationally Modified Knottins from the Deep-Sea Sponge

Lakmini N Kosgahakumbura, Blazej Slazak, Norelle L Daly, Rein Fadoul, Samia Mohamed, Erik Jacobsson, Ruisheng Xiong, Björn Hellman, Ulf Göransson, Chamari M Hettiarachchi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lakmini N KosgahakumburaPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden.
Blazej SlazakPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden.
Norelle L DalyAustralian Institute of Tropical Health and Medicine, James Cook University, 4870 Cairns, Queensland, Australia.ORCID 0000-0002-4697-6602
Rein FadoulDrug Safety and Toxicology, Department of Pharmaceutical Biosciences, Biomedical Center, SE-751 24 Uppsala, Sweden.
Samia MohamedPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden.
Erik JacobssonPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden.
Ruisheng XiongSciLifeLab, Department of Chemistry for Life Sciences, Uppsala University, Box 576, SE-75123 Uppsala, Sweden.
Björn HellmanDrug Safety and Toxicology, Department of Pharmaceutical Biosciences, Biomedical Center, SE-751 24 Uppsala, Sweden.
Ulf GöranssonPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden.
Chamari M HettiarachchiDepartment of Chemistry, University of Colombo, 00300 Colombo, Sri Lanka.ORCID 0000-0002-9557-751X
Paco CárdenasPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden.
Sunithi GunasekeraPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden.ORCID 0000-0002-1089-4015

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knottins are stable, structurally constrained mini-proteins with diverse bioactivities. This work presents the first report of a novel family of knottins, 'stryphnines', from the deep-sea sponge

Indexed as

PoriferaRibosomesAnimalsBiofoulingClostridium perfringensHumansMolecular StructureProtein Processing, Post-Translational

Identifiers

PMID42261690
PMCPMC13418204

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.