ArticleCureus2026
Enhancing Psychiatry Residents' Knowledge and Comfort With Clozapine Prescribing Through Educational Interventions.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionClozapine is the most effective antipsychotic for treatment-resistant schizophrenia but remains underutilized due to safety concerns and monitoring complexity. Recent discontinuation of the Clozapine Risk Evaluation and Mitigation Strategy (REMS) program reduced regulatory barriers but shifted responsibility for monitoring to clinicians. Psychiatry residents may lack adequate training and confidence to prescribe clozapine safely in this new context. The goal of this study is to evaluate the impact of a structured educational intervention on psychiatry residents' knowledge of clozapine prescribing and management.
methodsThis study was a single-institution quality improvement study using a pre-post design. Participants were psychiatry residents from PGY-1 to PGY-4. Participants underwent a one-hour structured educational session covering clozapine pharmacology, indications, monitoring, adverse effects, and post-REMS management. Outcomes assessed include knowledge assessment scores both before and after the educational session. A paired t-test comparing pre- and post-intervention scores was used to analyze the data.
resultsTen residents completed both assessments. Mean knowledge scores increased from 69.4% to 82.8% (mean increase 13.4 percentage points (19.3% relative increase); p < 0.05).
conclusionsA brief, targeted educational intervention was associated with improved psychiatry residents' knowledge regarding clozapine prescribing and management. Focused resident education may help mitigate barriers to clozapine use, particularly following REMS discontinuation. Incorporating structured clozapine training into residency curricula may promote safer and more appropriate use of clozapine in clinical practice.
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