Evidence map›Paper›PMID 42261460›Full record

ArticleJournal of asthma and allergy2026

Effectiveness of the P2X

Yoshihisa Ishiura, Shosaku Nomura, Noriyuki Ohkura, Johsuke Hara, Masaki Fujimura, Tomoki Ito

Abstract read
In one paragraph

Article in Journal of asthma and allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yoshihisa IshiuraFirst Department of Internal Medicine, Kansai Medical University, Osaka, Japan.ORCID 0000-0003-0320-1193
Shosaku NomuraFirst Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Noriyuki OhkuraRespiratory Medicine, Kanazawa University, Ishikawa, Japan.
Johsuke HaraRespiratory Medicine, Kanazawa University, Ishikawa, Japan.ORCID 0000-0003-0115-2615
Masaki FujimuraRespiratory Medicine, Kanazawa University, Ishikawa, Japan.
Tomoki ItoFirst Department of Internal Medicine, Kansai Medical University, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atopic cough, arising from hyperresponsiveness of afferent airway C-fibers, is common, and cough is one of the commonest reasons for referral to respiratory clinic. Gefapixant is a first-in-class P2X Methods: This was a single-center retrospective observational study. Patients with refractory atopic cough received gefapixant. Collected retrospectively from medical records, data included cough symptom questionnaire responses and results from respiratory function tests, cough reflex sensitivity tests, and blood tests. Results: Data from 23 patients with refractory atopic cough were included in this study. Spirometry parameters, fractional exhaled nitric oxide levels, peripheral eosinophil counts, and IgE levels were unchanged after gefapixant treatment. Scores for the cough severity visual analog scale and Leicester cough questionnaire significantly improved after treatment with gefapixant (both p<0.01). Cough reflex sensitivity to inhaled capsaicin also significantly improved after treatment with gefapixant (p<0.01). Conclusion: The P2X

Indexed as

atopic coughC-fiberscoughP2X3refractory chronic cough

Identifiers

PMID42261460
PMCPMC13242768

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.