Trial reportDrug design, development and therapy2026
Effect of Propofol Combined with Oliceridine versus Fentanyl on Desaturation During Gastrointestinal Endoscopy: A Randomized Clinical Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
15 authors.
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Abstract
Background: Propofol combined with fentanyl is widely used for gastrointestinal endoscopy sedation but may be associated with oxygen desaturation. Oliceridine, a G protein-biased μ-opioid receptor agonist, may have fewer opioid-related respiratory effects. We compared propofol-oliceridine with propofol-fentanyl for desaturation during gastrointestinal endoscopy. Methods: This single-center, double-blind, randomized clinical trial was conducted at Changshu No. 2 People's Hospital, China. Adults aged 18-65 years with ASA physical status I-II undergoing bidirectional gastrointestinal endoscopy were randomized 1:1 to receive propofol combined with either oliceridine 20 μg/kg or fentanyl 1 μg/kg. The primary outcome was mild desaturation, defined as SpO Results: Among 228 randomized patients, 224 were included in the modified intention-to-treat analysis. Mild desaturation occurred in 18 of 112 patients in the oliceridine group and 30 of 112 patients in the fentanyl group (16.1% vs 26.8%; unadjusted OR, 0.52; 95% CI, 0.27-1.01; P=0.053; adjusted OR, 0.49; 95% CI, 0.24-0.997; P=0.049). A full intention-to-treat sensitivity analysis including all randomized patients yielded consistent adjusted results (adjusted OR, 0.47; 95% CI, 0.23-0.95; P=0.035). Severe desaturation and airway intervention did not differ significantly between groups. Compared with the fentanyl group, the oliceridine group had lower incidences of SBP <90 mmHg, SBP <80 mmHg, and vasopressor use. Initial sedation success and intra-procedural MOAA/S sedation depth were comparable between groups. Conclusion: In this randomized clinical trial of patients undergoing bidirectional gastrointestinal endoscopy, propofol-oliceridine may reduce mild desaturation and hypotension compared with propofol-fentanyl while maintaining comparable intra-procedural sedation depth. Trial Registration: Chinese Clinical Trial Registry: ChiCTR2500096869.
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