ArticleCancer management and research2026
Determinants of Adverse Events in Patients with Cancer Who Practiced Self-Medication: A Cross-Sectional Study in Southwestern Uganda.
Article in Cancer management and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cancer therapies have been the cornerstone in cancer care. Co-morbidities and Adverse Events (AEs) often encourage some patients with cancer to resort to self-medication in search of relief or better symptom management. While self-medication is a key aspect of self-care and may offer some relief, it also poses risks, especially the potential for AEs. Limited data exist in Uganda, particularly at the Mbarara Regional Referral Hospital (MRRH) Cancer Unit, regarding the prevalence and determinants of AEs. Objective: To determine the prevalence and factors associated with AEs among self-medicating cancer patients at the MRRH Cancer Unit. Methods: A cross-sectional study was conducted from 1 Results: Out of 270 participants, 218 (80.7%) experienced AEs. Grade 1 was the most common (49.8%) followed by grade 2 (41.4%), and grade 3 (8.8%). The determinants of AEs included the use of alkylating agents (AOR=3.6, 95% confidence interval CI: 1.02-12.51; p-value= 0.046), self-medication with drugs for acid-related disorders (AOR=7.9, 95% CI: 1.79-35.41; p-value=0.006) and herbal medicines use (AOR=2.1, 95% CI: 1.09-4.22; p-value=0.026). Conclusion: AEs among self-medicating patients with cancer are highly prevalent at MRRH cancer unit. Therefore, implementing comprehensive medication review in this population, and applying active ADE risk classification and closer monitoring in high-risk patients, including those on any alkylating agents and those who use herbal products, is crucial to minimize the ADEs and ensure safe use these products.
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