ArticlePeerJ2026
Identification and validation of prognostic genes related to centrosome amplification in multiple myeloma.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Prognostic biomarkers associated with centrosome amplification-related genes (CARGs) in multiple myeloma (MM), a malignancy originating from bone marrow plasma cells, remain incompletely defined. This study aimed to identify CARG-associated prognostic genes in MM. Methods: Transcriptome data for MM and CARGs were obtained from public databases. Initially, differentially expressed genes (DEGs) from the GSE6477 dataset were intersected with CARGs to identify candidate genes, whose biological functions were then analyzed. Regression analyses were conducted to identify prognostic genes linked to CA, from which a risk model for stratification was developed. Further analyses included nomogram construction, functional pathway analysis, immune microenvironment assessment, immunotherapy response evaluation, and drug sensitivity testing. Prognostic gene expression was validated by reverse transcription-quantitative PCR (RT-qPCR). Results: Forty candidate genes were identified from the intersection of 946 DEGs and 784 CARGs, which were associated with biological processes such as spindle organization. Six prognostic genes- Conclusion: Six prognostic genes associated with CA in MM were identified, and a predictive risk model was developed, offering valuable insights for clinical prognosis and immunotherapy in MM.
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