Evidence map›Paper›PMID 42261097›Full record

ArticleNeurorehabilitation and neural repair2026

Wearable Myoelectric Interface for Neurorehabilitation (MINT) to Recover Arm Activity After Stroke: A Randomized Controlled Trial.

Abed Khorasani, Cynthia M Gorski, Na-Teng Hung, Joel Hulsizer, Vivek Paul, Goran Tomic, Prashanth R Prakash, Sangsoo Park, Gang Seo, Ethan J Houskamp and 13 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurorehabilitation and neural repair, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03401762 (Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03401762 narecruitingnot on this map

Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke

TypeinterventionalSponsorNorthwestern UniversityRan2018 to 2027Enrolled96ConditionsStroke, Stroke, AcuteArmsMCI, Sham MCI
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Abed KhorasaniDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Cynthia M GorskiDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Na-Teng HungDepartment of Neurology, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-0614-2849
Joel HulsizerDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Vivek PaulDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Goran TomicDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Prashanth R PrakashDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Sangsoo ParkDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Gang SeoDepartment of Biomedical Engineering, University of Houston, TX, USA.
Ethan J HouskampDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Jessica LanisDepartment of Physical and Occupational Therapy, Northwestern Medicine, Chicago, IL, USA.
Megan HunzekerDepartment of Physical and Occupational Therapy, Northwestern Medicine, Chicago, IL, USA.
Erin KingDepartment of Physical and Occupational Therapy, Northwestern Medicine, Chicago, IL, USA.ORCID 0000-0002-3724-3845
Anya ChappelDepartment of Physical and Occupational Therapy, Northwestern Medicine, Chicago, IL, USA.
Alix JampolDepartment of Physical and Occupational Therapy, Northwestern Medicine, Chicago, IL, USA.
Pooja PatelDepartment of Physical and Occupational Therapy, Northwestern Medicine, Chicago, IL, USA.
Catherine GallagherDepartment of Physical and Occupational Therapy, Northwestern Medicine, Chicago, IL, USA.
Rachel GalantShirley Ryan AbilityLab, Chicago, IL, USA.
Grace RuckerShirley Ryan AbilityLab, Chicago, IL, USA.
Jungwha LeeDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.
Richard L HarveyShirley Ryan AbilityLab, Chicago, IL, USA.
Jinsook RohDepartment of Biomedical Engineering, University of Houston, TX, USA.
Marc W SlutzkyDepartment of Neurology, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-2269-7729

Funding

Combining myoelectric training with sleep-based memory reactivation to improve motor recovery after strokeR01NS112942 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PALLER, KEN A, SLUTZKY, MARC W. · 2019 to 2023
$2.8M
MINT conditioning to improve post-stroke gaitR01HD113270 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Yasin Yousef Dhaher, Marc W. Slutzky · 2024 to 2026
$2.1M
A wearable myoelectric computer interface to reduce muscle co-activation in acute and chronic strokeR01NS099210 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SLUTZKY, MARC W. · 2016 to 2020
$1.7M
NICHD NIH HHS R01 HD113270NINDS NIH HHS R01 NS099210NINDS NIH HHS R01 NS112942
6 · The paper itself

Abstract

backgroundAbnormal muscle co-activation impairs arm function after stroke. Home-based myoelectric interface for neurorehabilitation (MINT) was developed to reduce abnormal co-activation.

objectiveEvaluate MINT feasibility and effects on arm activity in a single-blind, randomized, sham-controlled trial.

methodsModerately-to-severely impaired chronic stroke survivors were randomized to 1 of 3 MINT groups (who played customized games requiring independent activation of 2 or 3 abnormally co-activating muscles) or a sham control group (using 1 muscle). Participants trained 90 minutes/day, 6 days/week, switching upper-arm muscle sets every 2 to 3 weeks. Feasibility was assessed using training time, repetitions, and motivation. The primary efficacy outcome was the change in Wolf Motor Function Test (WMFT) from baseline to week 6 in each MINT group compared to sham. Secondary outcomes included WMFT at week 10, WMFT subscores, Fugl-Meyer, Modified Ashworth, Motor Activity Log, reaching kinematics, co-activation, and lesion location effects.

resultsFifty-nine participants completed training (mean: 86 ± 21 minutes/day, 315 ± 85 repetitions/day). The 3-muscle group improved WMFT by 6.8 seconds at week 6 (95% confidence interval [2.1-11.6 seconds], DISCUSSION: MINT conditioning is feasible, reduces co-activation, and improves arm movement and activity. CLINICAL

trial registrationClinicalTrials.gov (NCT03401762).

Indexed as

arm impairmentEMGgamingmovementmyoelectricstroke recoverystroke rehabilitationwearable

Identifiers

PMID42261097
PMCPMC13278386

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.