Evidence map›Paper›PMID 42261063›Full record

ArticleBiomedical chromatography : BMC2026

UPLC-QTOF-MS/MS and Antifungal Activity of a Fraction Enriched in Saponins From Sarcomphalus joazeiro Against Candida spp.

Ana Raquel Pereira da Silva, Maria do Socorro Costa, Nara Juliana Santos Araújo, Gabriel Gonçalves Alencar, Talysson Felismino Moura, Victor Juno Alencar Fonseca, Antônia Thassya Lucas Dos Santos, Maria Flaviana Bezerra Morais-Braga, Erlânio Oliveira de Souza, Josean Fechine Tavares and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical chromatography : BMC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ana Raquel Pereira da SilvaGraduate Program in Biotechnology, Universidade Estadual do Ceará (UECE), Fortaleza, Ceará, Brazil.
Maria do Socorro CostaGraduate Program in Biotechnology, Universidade Estadual do Ceará (UECE), Fortaleza, Ceará, Brazil.
Nara Juliana Santos AraújoLaboratory Applied Microbiology (LAMAP), Universidade Federal do Cariri (UFCA), Brejo Santo, Ceará, Brazil.
Gabriel Gonçalves AlencarLaboratory of Microbiology and Molecular Biology (LMBM), Universidade Regional do Cariri (URCA), Crato, Ceará, Brazil.
Talysson Felismino MouraLaboratory of Microbiology and Molecular Biology (LMBM), Universidade Regional do Cariri (URCA), Crato, Ceará, Brazil.
Victor Juno Alencar FonsecaDepartment of Biological Chemistry, Universidade Regional do Cariri (URCA), Crato, Ceará, Brazil.
Antônia Thassya Lucas Dos SantosDepartment of Biological Chemistry, Universidade Regional do Cariri (URCA), Crato, Ceará, Brazil.ORCID https://orcid.org/0000-0002-6433-3168
Maria Flaviana Bezerra Morais-BragaDepartment of Biological Chemistry, Universidade Regional do Cariri (URCA), Crato, Ceará, Brazil.
Erlânio Oliveira de SouzaFaculdade de Tecnologia do Cariri (FATEC), Juazeiro do Norte, Ceará, Brazil.
Josean Fechine TavaresDepartment of Pharmaceutical Sciences, Universidade Federal da Paraíba (UFPB), João Pessoa, Paraíba, Brazil.
Paulo Riceli Vasconcelos RibeiroNatural Products Chemistry Multiuser Laboratory (LMQPN), Embrapa Tropical Agroindustry, Fortaleza, Ceará, Brazil.
Jacqueline Cosmo Andrade-PinheiroLaboratory Applied Microbiology (LAMAP), Universidade Federal do Cariri (UFCA), Brejo Santo, Ceará, Brazil.
Henrique Douglas Melo CoutinhoLaboratory of Microbiology and Molecular Biology (LMBM), Universidade Regional do Cariri (URCA), Crato, Ceará, Brazil.ORCID https://orcid.org/0000-0002-6634-4207

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of antifungal resistance is a complex process that involves the interaction between hosts, drugs, and microbial factors, all of which contribute to therapeutic ineffectiveness. For this reason, studies on natural products as possible therapeutic alternatives are increasingly necessary in order to gain a better understanding of plant compounds that may be more effective in treating infections caused by fungal pathogens. In this context, this study aimed to investigate the antifungal potential of the saponin-enriched fraction of the Sarcomphalus joazeiro species against the Candida albicans, Candida tropicalis, and Candida krusei strains. The selection of this species for study is due to its rich phytochemical composition and the vast traditional knowledge of its medicinal properties. The fraction obtained from the stem bark of S. joazeiro was analyzed by UPLC-QTOF-MS/MS, in which compounds such as triterpenoids, flavonoids, acids, and saponins were identified. Therefore, the results obtained in this study contribute to understanding the antifungal potential of the S. joazeiro species fraction against fungal infections, especially those caused by Candida spp.

Indexed as

Antifungal AgentsCandidaPlant ExtractsSaponinsChromatography, High Pressure LiquidMicrobial Sensitivity TestsTandem Mass SpectrometryAntifungal AgentsPlant ExtractsSaponinsantifungal activityflavonoidsliquid chromatographysaponins

Identifiers

PMID42261063
PMCPMC13247535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.