Maternal Thyroid Diseases, Medication Use and Childhood Cancer Risks in Offspring: A Population-Based Cohort Study in Denmark.

Chuanjie Deng, Kosuke Inoue, Chai Saechao, Johnni Hansen, Beate Ritz, Julia E Heck

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Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Chuanjie DengDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-7069-4237

Kosuke InoueDepartment of Health Promotion and Human Behavior, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Chai SaechaoUCLA Health, University of California, Los Angeles, California, USA.

Johnni HansenDanish Cancer Institute, Danish Cancer Society, Copenhagen, Denmark.

Beate RitzDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, USA.

Julia E HeckDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, USA.

Funding

Maternal comorbidities, prescription drug use in pregnancy and childhood cancerR21CA175959 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2014 to 2015

$323k

NCI NIH HHS R21 CA175959NIH HHS R21CA175959

6 · The paper itself

Abstract

Thyroid diseases are common among women of reproductive age and may be related to childhood cancer among offspring, though the evidence is inconsistent. Using Danish registries, we conducted a population-based case-control study to investigate the relationship between maternal thyroid diseases and medication use and childhood cancer among offspring. Cases (N = 2521) diagnosed between 1973 and 2016 were ascertained from the Danish Cancer Registry, and controls (N = 63,014) were randomly selected from the Central Population Registry and matched on sex and date of birth. Information on diagnoses and prescriptions was obtained from the National Patient Register and the National Prescription Register, respectively. Conditional logistic regression was applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Goiter was associated with any cancer (OR = 2.08, 95% CI: 1.44, 3.00), leukemia (OR = 2.18, 95% CI: 1.13, 4.18), acute lymphoblastic leukemia (OR = 2.12, 95% CI: 1.02, 4.42), and lymphoma (OR = 3.06, 95% CI = 1.20, 7.82). There was no observed association between childhood cancer and maternal hypothyroidism or hyperthyroidism; however, these results were likely underpowered. No increased risk of cancer was observed for maternal thyroid medication use. Though the small sample size must be considered, the elevated risk of cancer with maternal thyroid diseases, especially goiter, was notable.

Indexed as

NeoplasmsPregnancy ComplicationsPrenatal Exposure Delayed EffectsThyroid DiseasesAdolescentAdultCase-Control StudiesChildChild, PreschoolCohort StudiesDenmarkFemaleGoiterHumansHyperthyroidismInfantchildhood cancerDanish population‐base studymaternal diseasethyroid diseasethyroid medication

Identifiers

PMID42260983

DOI10.1002/ijc.70576

PMCPMC13495921

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