Evidence map›Paper›PMID 42260964›Full record

ReviewJournal of traumatic stress2026

Artificial intelligence in traumatic stress treatment: The TRUST framework for ethical development, clinical applications, and research advancement.

Leigh E Ridings, Philip Held, Eric Kuhn, Shannon Wiltsey-Stirman

Abstract readReview
In one paragraph

Review in Journal of traumatic stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leigh E RidingsCollege of Nursing, Medical University of South Carolina, Charleston, South Carolina, USA.
Philip HeldDepartment of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA.
Eric KuhnDissemination and Training Division, National Center for PTSD, VA Palo Alto Healthcare System, Menlo Park, California, USA.
Shannon Wiltsey-StirmanDissemination and Training Division, National Center for PTSD, VA Palo Alto Healthcare System, Menlo Park, California, USA.

Funding

The South Carolina Clinical & Translational Research Institute (SCTR)UM1TR005294 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KATHLEEN T. BRADY, PATRICK A FLUME · 2025 to 2026
$7.6M
Evaluation of a Multiagent LLM-Based Simulated Patient to Train Therapists in Written Exposure Therapy for PTSDP50MH139450 · NIMH · STANFORD UNIVERSITY · PI Johannes C. Eichstaedt, SHANNON Wiltsey STIRMAN · 2025 to 2026
$7.0M
The Use of a Smartphone Application to Improve Delivery of an Integrated PTSD and SUD Intervention for Sexual Assault SurvivorsP20GM156709 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Marvella Elizabeth Ford · 2025 to 2026
$6.8M
Improving Quality of Life and Behavioral Health Service Access for Caregivers and Young Children after Pediatric Traumatic InjuryR01HD117024 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Leigh E. Ridings · 2025 to 2026
$1.4M
A Scalable mHealth Resource to Facilitate Behavioral and Emotional Recovery after Pediatric Traumatic Injury - SuplementK23HD098325 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RIDINGS, LEIGH E. · 2020 to 2024
$794k
NCATS NIH HHS UM1 TR005294NICHD NIH HHS K23 HD098325NICHD NIH HHS R01 HD117024NIGMS NIH HHS P20 GM156709NIMH NIH HHS P50 MH139450
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) and depression are common diagnoses following traumatic events, with several available evidence-based interventions to reduce symptomology. However, trauma populations face significant access barriers that limit their adoption and reach. Artificial intelligence (AI) technologies, such as large language models (LLMs), have the potential to enhance access, cost-efficiency, delivery, and quality of traumatic stress interventions. Their application to traumatic stress treatment and research is understudied and requires responsible and ethical development, evaluation, and monitoring to maintain service quality and delivery for trauma survivors and their providers. We present considerations for the responsible use of AI tools to ethically shape trauma-focused treatment and research, with future use cases to highlight these critical considerations. A multidisciplinary approach to trauma-based LLM development that integrates feedback and evaluation from trauma experts, clinicians, and trauma survivors and prioritizes the quality, safety, effectiveness, and equity of trauma-focused care is essential. We propose a framework, TRUST, that is informed by evidence from adjacent mental health AI applications and emerging research on digital trauma interventions, while acknowledging the limited trauma-specific AI trial data. These topics were presented at the 41st Annual Meeting of the International Society for Traumatic Stress Studies via a panel of experts in AI technologies to support trauma-focused interventions.

Identifiers

PMID42260964
PMCPMC13504747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.