Evidence map›Paper›PMID 42260949›Full record

ArticleMolecular pharmaceutics2026

Eutectic-Driven Recrystallization of Coamorphous Bicalutamide + Niclosamide Systems: Contrasting Stability above and below

Paulina Poloczek, Justyna Knapik-Kowalczuk, Joanna Klimontko, Xue Han, Kohsaku Kawakami, Marian Paluch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paulina PoloczekInstitute of Physics, University of Silesia in Katowice, 75 Pułku Piechoty 1A, Chorzów 41-500, Poland.
Justyna Knapik-KowalczukInstitute of Physics, University of Silesia in Katowice, 75 Pułku Piechoty 1A, Chorzów 41-500, Poland.ORCID 0000-0003-3736-8098
Joanna KlimontkoInstitute of Physics, University of Silesia in Katowice, 75 Pułku Piechoty 1A, Chorzów 41-500, Poland.
Xue HanResearch Center for Macromolecules and Biomaterials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
Kohsaku KawakamiResearch Center for Macromolecules and Biomaterials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.ORCID 0000-0002-3466-9365
Marian PaluchInstitute of Physics, University of Silesia in Katowice, 75 Pułku Piechoty 1A, Chorzów 41-500, Poland.ORCID 0000-0002-7280-8557

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coamorphization is a promising strategy to enhance the physical stability of poorly water-soluble drugs. However, the relationship between composition, molecular dynamics, and long-term stability remains insufficiently understood. Here, we investigate coamorphous systems composed of bicalutamide (BIC) and niclosamide (NIC), focusing on how the eutectic composition defined in the crystalline state translates into molecular dynamics and long-term physical stability of the corresponding amorphous systems above and below the glass transition temperature (

Indexed as

AnilidesNiclosamideNitrilesTosyl CompoundsCalorimetry, Differential ScanningCrystallizationDielectric SpectroscopyDrug StabilityMolecular Dynamics SimulationSolubilityTransition TemperatureX-Ray DiffractionAnilidesbicalutamideNiclosamideNitrilesTosyl Compoundsbicalutamidecoamorphous systemseutectic compositionmolecular mobilityniclosamidephysical stability

Identifiers

PMID42260949
PMCPMC13343511

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.