ArticleLangmuir : the ACS journal of surfaces and colloids2026
From Colloids to Hydrogels: Concentration-Dependent Cytocompatibility of Carboxylated Cellulose Nanocrystals Prepared via Deep Eutectic Solvents.
Article in Langmuir : the ACS journal of surfaces and colloids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cellulose nanocrystals (CNCs) are promising sustainable nanomaterials, yet their application in biointerfaces is often limited by fixed surface chemistries and limited insight into their concentration-dependent behavior. Here, we report a green and scalable strategy for CNC surface reprogramming using an oxalic acid-choline chloride deep eutectic solvent (ChCl-OAD DES), enabling controlled substitution of sulfate groups with carboxyl functionalities under mild conditions. The resulting carboxylated CNCs (CNC-COOH) preserve crystallinity and morphology while achieving tunable surface charge densities (up to ∼0.19 mequiv g
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