ArticleItalian journal of pediatrics2026
Risk factors analysis of poor prognosis in ICU-admitted children with severe influenza pneumonia: a retrospective case-control study.
Article in Italian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study investigated independent prognostic risk factors for adverse outcomes in children admitted to the ICU with severe influenza pneumonia to guide early risk stratification and timely clinical intervention.
methodsThis retrospective study included 139 eligible pediatric ICU patients with severe influenza pneumonia. Univariate and multivariate logistic regression was applied to analyze the independent risk factors for poor prognosis with severe influenza pneumonia, and the Receiver operating characteristic (ROC) curve was used to evaluate the effectiveness of risk factors.
resultsAmong the 139 children, 45 had a poor prognosis and 94 had a good prognosis. Multiple clinical and laboratory parameters differed significantly between the two groups (all P[Formula: see text]0.05). The three independent risk factors associated with poor prognosis were identified: fever peek [Formula: see text]41[Formula: see text](Odds ration [OR] [Formula: see text] 13.584, P[Formula: see text] 0.036), requirement for invasive mechanical ventilation (IMV) (OR [Formula: see text] 47.526, P[Formula: see text] 0.006), and elevated interleukin-6 (IL-6) levels (OR [Formula: see text] 1.049, P[Formula: see text] 0.002).The optimal cut-off value of IL-6 for predicting poor prognosis was 492.05 pg/mL (Area under the Curve [AUC] [Formula: see text] 0.755; sensitivity 46.7[Formula: see text], specificity 94.7[Formula: see text]; 95[Formula: see text] Confidence Interval [CI]: 0.666-0.844). The AUCs for fever peak [Formula: see text] 41[Formula: see text] and IMV were 0.623 and 0.737, respectively, whereas the combined AUC for all three indicators reached 0.848 [Formula: see text]95[Formula: see text] CI: 0.784-0.912).
conclusionFever peak [Formula: see text]41[Formula: see text], requirement for IMV, and IL-6 levels exceeding 492.05 pg/mL are robust independent early predictors of poor prognosis in children admitted to the ICU with severe influenza pneumonia. Combined assessment of these markers demonstrates strong predictive performance and supports targeted early intervention in high-risk patients.
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