ArticleSkeletal muscle2026
Declining muscle hyperplasia in juvenile trout is associated with a significant impairment of the supportive function of the myogenic progenitor niche.
Article in Skeletal muscle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUnlike mammals and birds, where new muscle fiber formation (hyperplasia) ceases around birth, large and fast-growing fish such as trout undergo a spectacular post-hatching surge of hyperplasia, followed by a considerably delayed hyperplasia decline. This study investigated the role of muscle stem cells (MuSCs) and their niche in this process by assessing changes in their abundance, myogenic potential and niche functionality.
methodsHyperplasia kinetics were investigated by measuring the total number of fibers and their cross-sectional area (CSA) in white muscle across juvenile stages (10 g to 2 kg). Quantification of MuSCs during growth was performed by pax7 in situ hybridization. To assess the supportive capacity of the MuSCs niche, muscle-derived cells (MDCs) extracted from the Tg(mlc2:gfp) trout line were transplanted into muscle of wild-type trout at different juvenile stages. Expression of GFP in transplanted muscle was measured as an indicator of myogenic progenitor differentiation.
resultsHistological analysis revealed a significant decrease in hyperplasia and MuSCs density (defined here as pax7
conclusionsOverall, these results indicate that the decline in muscle hyperplasia in trout is associated with an early impairment of the MuSC niche, along with a reduced MuSC density. Also, weight gain was found to play a more critical role than aging. These original findings provide new insights into the mechanisms underlying muscle growth as hyperplasia declines in vertebrates.
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