ArticleBMC microbiology2026
Study on metabolic differences and microbiota distribution in patients with infection-induced kidney stones by gender.
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to investigate the distribution patterns of microbiota and stone composition in patients with infection-induced stones across different genders, and to elucidate the differences between stone composition and metabolism.
methodsClinical data from 355 patients with infection stones (confirmed by postoperative stone composition analysis) who were hospitalized and treated at our center from January 2016 to December 2023 were retrospectively analyzed. The collected data included preoperative mid-stream urine culture results, serum biochemical parameters, 24-hour urinary metabolic indices, and postoperative stone composition analysis. The patients were divided into two groups based on gender to analyze the distribution of stone composition and microbiota. Metabolic differences between the groups were assessed based on blood biochemical markers and 24-hour urinary metabolic test results.
resultsOf the 355 cases, struvite-carbonate apatite mixed stones were most frequent overall and in females (P < 0.05), while pure struvite stones dominated in males (P < 0.05). Microbiota distribution showed E. coli was most common in females and P. aeruginosa in males (P < 0.05). Females had significantly higher serum phosphorus, chlorine, and eGFR (P < 0.05), whereas males had higher blood urea nitrogen, creatinine, and uric acid (P < 0.05). Additionally, 24-hour urinary phosphorus, chlorine, and sodium excretions were greater in males (P < 0.05).
conclusionThis study found significant gender differences in the microbial distribution, stone composition, and metabolic characteristics of patients with infection stones. These findings suggest that more comprehensive metabolic evaluation and urine culture may be of help in optimizing clinical management. Additionally, the study observed that male patients with infection stones tended to have relatively poorer renal function-related indicators, suggesting that this population might benefit from more timely and effective clinical attention and intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.