ReviewCommunications biology2026
Molecular insights into DNA damage response plasticity in glioma stem cells.
Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
High-grade gliomas frequently recur after radiotherapy and temozolomide because tumor cells can adapt to sustained DNA damage. This Review discusses how glioma stem cells contribute to this resistance by rewiring the DNA damage response rather than simply increasing DNA repair efficiency. We examine how checkpoint signaling, replication stress tolerance, DNA repair pathway choice, chromatin and RNA-based regulation, translational control, metabolism and microenvironmental cues cooperate to preserve survival under genotoxic stress. By integrating these mechanisms, we define DNA damage response plasticity as an adaptive network that supports tumor persistence and recurrence, while exposing vulnerabilities that may guide more effective therapeutic strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.