Evidence map›Paper›PMID 42260300›Full record

ArticleNature immunology2026

The embryonic origins of site-specific arthritis.

Sarah Davidson, Davide Simone, Kathrin Jansen, Max Cowan, Caio Machado, Ian Reekie, Ananya Bhalla, Rowie Borst, Cesar Prada Medina, Joshua Bull and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Sarah Davidson *Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Davide Simone *Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0241-5387
Kathrin Jansen *Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3803-7680
Max CowanKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Caio MachadoKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Ian ReekieKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2542-7329
Ananya BhallaKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Rowie BorstKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2165-9894
Cesar Prada MedinaKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Joshua BullMathematical Institute, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1475-2898
Zhi Yi WongKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Sarah HillKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0009-0004-2423-591X
Micon GarvillesKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Sam PledgerKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Patricia Reis NisaRheumatology Research Group, University of Birmingham, Birmingham, UK.
Nora Rebecca SchwingenKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Dylan WindellKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Moustafa AttarKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-4116-1276
Catherine DisneyDiamond Light Source, Harwell Science and Innovation Campus, Oxford, UK.
Andrew J BodeyDiamond Light Source, Harwell Science and Innovation Campus, Oxford, UK.
Alissa ParmenterDepartment of Mechanical Engineering, University College London, London, UK.ORCID http://orcid.org/0000-0002-9836-8932
Helen ByrneMathematical Institute, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1771-5910
Sharif AhmedDiamond Light Source, Harwell Science and Innovation Campus, Oxford, UK.
Shashidhara MaratheDiamond Light Source, Harwell Science and Innovation Campus, Oxford, UK.ORCID http://orcid.org/0000-0002-7662-8465
Peter D LeeDepartment of Mechanical Engineering, University College London, London, UK.ORCID http://orcid.org/0000-0002-3898-8881
Chris MahonyRheumatology Research Group, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0003-4487-2540
Adam P CroftRheumatology Research Group, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-9487-0511
Stephen SansomKennedy Institute of Rheumatology, University of Oxford, Oxford, UK. stephen.sansom@kennedy.ox.ac.uk.ORCID http://orcid.org/0000-0003-4569-8513
Mark C ColesKennedy Institute of Rheumatology, University of Oxford, Oxford, UK. mark.coles@kennedy.ox.ac.uk.ORCID http://orcid.org/0000-0001-8079-9358
Christopher D BuckleyKennedy Institute of Rheumatology, University of Oxford, Oxford, UK. christopher.buckley@kennedy.ox.ac.uk.ORCID http://orcid.org/0000-0001-6924-6402

Funding

PEARL: Pathway Exploration and Analysis in Renal LupusUH2AR067688 · NIAMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DIAMOND, BETTY, WOFSY, DAVID · 2014 to 2020
$9.0M
Tissue Acquisition Research GroupUM2AR067678 · NIAMS · STANFORD UNIVERSITY · PI HOLERS, VERNON MICHAEL, UTZ, PAUL JOSEPH · 2014 to 2020
$8.2M
Multi-Ethnic Translational Research Optimization (METRO) Lupus ConsortiumUH2AR067689 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUYON, JILL P, PUTTERMAN, CHAIM · 2014 to 2020
$6.3M
Evolving Adaptive and Effector Mechanisms from Pre-RA Through Established DiseaseUH2AR067681 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI HOLERS, VERNON MICHAEL · 2014 to 2020
$5.5M
Molecular and Cellular Dissection of Early Rheumatoid ArthritisUH2AR067694 · NIAMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI BRENNER, MICHAEL B., GREGERSEN, PETER K. · 2014 to 2020
$5.4M
RA-SLE Molecular Deconstruction Leadership CenterUH2AR067677 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B., RAYCHAUDHURI, SOUMYA · 2014 to 2020
$4.3M
Cellular Dynamics at the Synovium-Bone interface in RAUH2AR067690 · NIAMS · UNIVERSITY OF ROCHESTER · PI ANOLIK, JENNIFER HOWITT · 2014 to 2020
$3.0M
Stanford Technology Accelerating Medicines Partnership CenterUH2AR067676 · NIAMS · STANFORD UNIVERSITY · PI ROBINSON, WILLIAM H, UTZ, PAUL JOSEPH · 2014 to 2020
$2.6M
Accelerating Medicines Partnership in RA and Lupus: Network Sites (UH2/UH3)UH2AR067679 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI PETRI, MICHELLE A · 2014 to 2020
$2.1M
Molecular Pathways in Treatment Response and Flare in RAUH2AR067691 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI BYKERK, VIVIAN P, IVASHKIV, LIONEL B · 2014 to 2020
$2.0M
UPITT Rheumatoid Arthritis Combined Center (UPITT RACC)UH2AR067685 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCGEACHY, MANDY J, MORELAND, LARRY W · 2014 to 2019
$1.2M
NIAMS NIH HHS UH2 AR067676NIAMS NIH HHS UH2 AR067677NIAMS NIH HHS UH2 AR067679NIAMS NIH HHS UH2 AR067681NIAMS NIH HHS UH2 AR067685NIAMS NIH HHS UH2 AR067688NIAMS NIH HHS UH2 AR067689NIAMS NIH HHS UH2 AR067690NIAMS NIH HHS UH2 AR067691NIAMS NIH HHS UH2 AR067694NIAMS NIH HHS UM2 AR067678RCUK | Medical Research Council (MRC) MR/S025308/1RCUK | Medical Research Council (MRC) MR/S035850/1RCUK | Medical Research Council (MRC) MR/X012093/1RCUK | MRC | Medical Research Foundation MR/S035850/1
6 · The paper itself

Abstract

The cellular basis for site-specific inflammation remains unclear. In human fingers, proximal interphalangeal (PIP) joints are preferentially affected by inflammatory arthritis, whereas distal interphalangeal joints are spared, providing a model to investigate the predilection of inflammation to distinct sites. Here we combine single-cell RNA sequencing, imaging and X-ray tomography to examine cellular composition, spatial organization and structure of finger joints during fetal development. PIP joints had a larger synovial volume and were enriched for PI16

Indexed as

ArthritisFibroblastsFinger JointAnimalsFemaleHumansMesenchymal Stem CellsSingle-Cell AnalysisSynovial Membrane

Identifiers

PMID42260300
PMCPMC13310765

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.