Evidence map›Paper›PMID 42260245›Full record

ArticleLangenbeck's archives of surgery2026

A novel real-time assessment of intestinal perfusion with dual imaging using ICG fluorescence and capillaroscopy in colorectal surgery.

Sadahito Iseki, Takeshi Aoki, Makoto Watanabe, Ryohei Watanabe, Tetsuya Kitajima, Keisuke Oura, Shun Miyasaka, Yusuke Uchida, Koya Sekiguchi, Yasuyuki Ohira and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sadahito IsekiDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Takeshi AokiDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan. takejp@med.showa-u.ac.jp.
Makoto WatanabeDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Ryohei WatanabeDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Tetsuya KitajimaDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Keisuke OuraDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Shun MiyasakaDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Yusuke UchidaDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Koya SekiguchiDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Yasuyuki OhiraDepartment of Pathology, School of Medicine, Showa Medical University, Tokyo, Japan.
Kodai TomiokaDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Hideki ShibataDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Yoshihiko TashiroDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Koji NogakiDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Hiromi DateDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Kazuhiro MatsudaDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Kimiyasu YamazakiDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Hiroki YamaueDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa Medical University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8666, Japan.
Toshiko YamochiDepartment of Pathology, School of Medicine, Showa Medical University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAnastomotic leakage (AL) is a major complication after colorectal surgery. Indocyanine green fluorescence imaging (ICG-FI) enables real-time assessment of intestinal perfusion, but remains subjective. This study quantitatively evaluated intestinal perfusion by combining ICG-FI with video capillaroscopy (VC).

methodsThirty-two patients undergoing colorectal surgery were enrolled. ICG was administered intravenously before anastomosis. Fluorescence time was defined as the interval from injection to initial fluorescence at the anastomotic site. Microvascular blood-flow velocity was measured intraoperatively using VC in fluorescent and non-fluorescent regions.

resultsAL occurred in 4 of 32 patients (12.5%). The AL group had significantly longer fluorescence time than the non-AL group (32.0 [25.3-34.3] vs. 20.0 [17.3-25.0] s, p = 0.014) and tended to have lower microvascular flow velocity in ICG-fluorescent regions (90.8 [49.0-249.8] vs. 231.7 [164.6-327.3] µm/s, p = 0.064). ROC analysis showed discriminative performance for fluorescence time (AUC 0.88, preliminary cutoff 32 s) and flow velocity (AUC 0.79, preliminary cutoff 101.6 μm/s). Fluorescence time and flow velocity were negatively correlated (r = - 0.41, p = 0.0195).

conclusionsDelayed fluorescence appearance on ICG-FI was associated with reduced VC-derived microvascular flow velocity. To our knowledge, this is the first study to integrate ICG-FI and VC intraoperatively for quantitative assessment of intestinal perfusion. Combined ICG-FI and VC assessment may provide physiological support for interpreting delayed fluorescence as a potential marker of microcirculatory impairment. Further validation is required to determine its clinical utility.

Indexed as

Anastomotic LeakColorectal NeoplasmsIndocyanine GreenMicroscopic AngioscopyAgedAged, 80 and overAnastomosis, SurgicalColorectal Surgical ProceduresColoring AgentsFemaleHumansMaleMicrocirculationMiddle AgedColoring AgentsIndocyanine GreenAnastomotic leakageBlood perfusionCapillaroscopyColorectal surgeryIndocyanine green fluorescence

Identifiers

PMID42260245
PMCPMC13469217

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.