Evidence map›Paper›PMID 42260155›Full record

ArticleScientific reports2026

Environmental context related to hydrogen sulphide and regional variation in utilisation of ROCK inhibitors in Japan: a nationwide ecological analysis.

Ryosuke Shinkai, Takahiro Amemiya, Takashi Tomita

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ryosuke ShinkaiDepartment of Pharmaceutical Sciences, School of Pharmacy at Narita, International University of Health and Welfare, 4-3 Kozunomori, Narita, 286-8686, Japan. r-shinkai@ihwg.jp.
Takahiro AmemiyaFaculty of Pharmaceutical Sciences, Teikyo Heisei University, 4-21-2 Nakano, Nakano-ku, Tokyo, 164-8530, Japan.
Takashi TomitaDepartment of Pharmaceutical Sciences, School of Pharmacy at Narita, International University of Health and Welfare, 4-3 Kozunomori, Narita, 286-8686, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regional variation in healthcare utilisation is widely documented, yet the contribution of natural environmental context to prescribing patterns remains poorly understood. Geological environments shape long-term background exposure to naturally occurring substances, but population-level evidence linking geological context to ophthalmic prescribing is limited. Experimental studies have suggested that hydrogen sulphide (H

Indexed as

Hydrogen SulfideIsoquinolinesProtein Kinase Inhibitorsrho-Associated KinasesCross-Sectional StudiesHumansJapanOphthalmic SolutionsSulfonamidesHydrogen SulfideIsoquinolinesK-115Ophthalmic SolutionsProtein Kinase Inhibitorsrho-Associated KinasesSulfonamides

Identifiers

PMID42260155
PMCPMC13490513

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.