Evidence map›Paper›PMID 42260150›Full record

ArticleScientific reports2026

Larval habitat drives differential selection pressures on genetic insecticide resistance and metabolic enzyme plasticity in Anopheles gambiae s.l during laboratory colonization.

Ibrahim K Gyimah, Godwin K Amlalo, Rebecca Pwalia, Samuel S Akporh, Aaron A Lartey, Akua O Y Danquah, Dominic Acquah-Baidoo, Sampson Gbagba, Ali B I Alhassan, Joannitta Joannides and 6 more

Abstract read
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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ibrahim K GyimahVestergaard-NMIMR Vector Labs, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana. igyimah@noguchi.ug.edu.gh.
Godwin K AmlaloVestergaard-NMIMR Vector Labs, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
Rebecca PwaliaVestergaard-NMIMR Vector Labs, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
Samuel S AkporhVestergaard-NMIMR Vector Labs, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
Aaron A LarteyVestergaard-NMIMR Vector Labs, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
Akua O Y DanquahVestergaard-NMIMR Vector Labs, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
Dominic Acquah-BaidooVestergaard-NMIMR Vector Labs, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
Sampson GbagbaVestergaard-NMIMR Vector Labs, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
Ali B I AlhassanVestergaard-NMIMR Vector Labs, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
Joannitta JoannidesVestergaard-NMIMR Vector Labs, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
Samuel O DarkwahVestergaard-NMIMR Vector Labs, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
Godwin A KoffaDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
Duncan K AthinyaVestergaard Frandsen (EA) Limited, 14 Riverside, Belgravia Block, 6th Floor, Nairobi, Kenya.
Rinki DebVestergaard Sàrl, Place Saint François 1, 1003, Lausanne, Switzerland.
Samuel K DadzieDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
Jewelna AkorliDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana. jakorli@noguchi.ug.edu.gh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The evolution of insecticide resistance in mosquitoes is shaped by direct insecticide exposure and environmental conditions encountered during development. This study used an experimental evolution approach to investigate how larval habitats select for insecticide resistance profiles in An. gambiae s.l. over 10 successive generations. Mosquito larvae were collected from a single site in Accra, Ghana, and reared separately in three water types: field-collected water (FW), dechlorinated tap water (TW), and distilled water (DW) for 10 filial generations. At each generation, phenotypic susceptibility to four classes of insecticides was assessed using WHO bioassays, including synergist assays with piperonyl butoxide (PBO) and, the frequencies of the kdr-w (L995F) and ace-1 (G119S) target-site mutations were determined molecularly. Activity of detoxification enzymes, P450 monooxygenases, α- and β-carboxylesterases, and insensitive acetylcholinesterase were measured biochemically. Key selected physicochemical properties of the rearing waters were also characterized to provide contextual information on potential larval environmental influences. kdr-w mutation rapidly increased to fixation by generation F

Indexed as

AnophelesEcosystemInsecticide ResistanceSelection, GeneticAnimalsGhanaInsecticidesLarvaMutationInsecticidesAce-1(G119S)Anopheles gambiae s.l.Experimental evolutionInsecticide resistanceKdr-w (L995)Larval habitatLarval source managementMetabolic resistance

Identifiers

PMID42260150
PMCPMC13490596

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.