ArticleScientific reports2026
Paper-based laser-written CoO-graphene biosensor for wireless sweat uric acid detection.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Uric acid is a critical metabolic biomarker for gout, kidney dysfunction, and cardiovascular disease. Persistent hyperuricemia promotes monosodium urate crystal deposition, triggering recurrent gout flares, chronic joint damage, and systemic inflammation, while early and continuous uric acid monitoring enables timely therapeutic intervention and improved disease outcomes. However, conventional blood tests and enzymatic sensors, although reliable, remain invasive, laboratory-bound, and unsuitable for continuous or point-of-care monitoring. Herein, we report a sustainable one-step strategy to fabricate a non-enzymatic uric acid sensor by direct laser writing on cobalt-treated paper with 455 nm irradiation, producing cobalt oxide-infused graphene. Unlike conventional metal-functionalized laser-induced graphene (LIG), which typically requires multi-step processing and non-biodegradable polymeric substrates, the present approach employs a biomass-derived paper substrate and simultaneously generates conductive graphene and redox-active cobalt oxide nanostructures in a single photothermal process. Furthermore, the incorporated multivalent Co
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