Evidence map›Paper›PMID 42260132›Full record

ArticleScientific reports2026

MicroRNA-125a-5p promotes NLRP3/caspase-1/GSDMD pathway-mediated pyroptosis in endothelial cells during Kawasaki disease.

Ying Li, Zhixiang Wu, Min Kong, Zhijuan Kang, Lu Yi, Yanan Hu, Qin He, Yuanbojiao Zuo, Zhuoying Li, Zuocheng Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ying LiDepartment of Pediatrics, the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Zhixiang WuDepartment of Pediatrics, the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Min KongDepartment of Pediatrics, the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Zhijuan KangDepartment of Pediatrics, the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Lu YiDepartment of Pediatrics, the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Yanan HuDepartment of Pediatrics, the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Qin HeDepartment of Pediatrics, the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Yuanbojiao ZuoDepartment of Pediatrics, the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Zhuoying LiDepartment of Pediatrics, the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Zuocheng YangDepartment of Pediatrics, the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. yang_zcr@126.com.

Funding

Natural Scientific Foundation of China Grant no. 81800440Philosophy and Social Science Foundation of Hunan Province 19YBA351
6 · The paper itself

Abstract

Kawasaki disease (KD) is an acute systemic vasculitis that the primary cause of secondary heart disease in children. Dysregulation of microRNA (miRNA) expression drives gene expression patterns across multiple biological processes, thereby mediating the pathogenesis and progression of KD. This study investigated how miR-125a-5p regulates pyroptosis in KD-associated endothelial cells. This study used Lactobacillus casei cell-wall extract (LCWE) to stimulate male C57BL/6 mice and human umbilical vein endothelial cells (HUVECs) to establish KD-like models. Experimental data demonstrated marked upregulation of miR-125a-5p expression in both KD-associated models. In vitro analysis revealed that targeted inhibition of miR-125a-5p increased HUVEC survival while reducing NLRP3/caspase-1/GSDMD-driven pyroptosis. In vivo, targeted inhibition of miR-125a-5p inactivated the NLRP3/caspase-1/GSDMD signaling pathway and diminished pyroptosis and inflammation in coronary artery tissues. This study found that miR-125a-5p exacerbates LCWE-induced pyroptosis in HUVECs and vascular injury in mice, suggesting a potential therapeutic strategy targeting miR-125a-5p for KD-related endothelial injury and inflammation.

Indexed as

Caspase 1Endothelial CellsIntracellular Signaling Peptides and ProteinsMicroRNAsMucocutaneous Lymph Node SyndromeNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisAnimalsDisease Models, AnimalGasderminsHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLSignal TransductionCaspase 1GasderminsIntracellular Signaling Peptides and ProteinsMicroRNAsMIRN125 microRNA, humanMirn125 microRNA, mouseNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseEndothelial injuryKawasaki diseasemiR-125a-5pNLRP3Pyroptosis

Identifiers

PMID42260132
PMCPMC13486843

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.