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ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2026

The status of health-related quality of life among older adults with overactive bladder: a cross-sectional analysis of the Yamagata Cohort Study in Japan.

Norihiko Tsuchiya, Mayu Yagi, Hayato Nishida, Sei Naito, Atsushi Yamagishi, Takafumi Narisawa, Hiroki Fukuhara, Yuki Takai, Shinta Suenaga, Suguru Ito and 2 more

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Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Norihiko TsuchiyaDepartment of Urology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan. ntsuchiya@med.id.yamagata-u.ac.jp.ORCID http://orcid.org/0000-0003-4242-2618
Mayu YagiDepartment of Urology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Hayato NishidaDepartment of Urology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Sei NaitoDepartment of Urology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Atsushi YamagishiDepartment of Urology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Takafumi NarisawaDepartment of Urology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Hiroki FukuharaDepartment of Urology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Yuki TakaiDepartment of Urology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Shinta SuenagaDepartment of Urology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Suguru ItoDepartment of Urology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Tsuneo KontaDepartment of Public Health, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Satoru NagaseWell-Being Institute, Faculty of Medicine, Yamagata University, Yamagata, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOveractive bladder (OAB) is prevalent among older adults and may substantially affect health-related quality of life (HRQoL). This study aimed to describe HRQoL status among community-dwelling older adults with OAB and examine the relationship between OAB symptom severity and HRQoL.

methodsA cross-sectional analysis was conducted using data from 12,212 participants aged ≥ 65 years in the Yamagata Cohort Study (2021-2022). Multiple imputation was used to handle missing data. OAB was assessed using the OABSS (total score ≥ 3 and urgency score ≥ 2), and HRQoL was measured using the EQ-5D-5L utility score and EQ VAS. Multiple regression analyses were performed, adjusting for age, sex, BMI, and comorbidities.

resultsParticipants with OAB (n = 2,864, 27.9%) had significantly lower EQ-5D-5L utility scores (β = - 0.057; 95% CI - 0.063, - 0.052) and EQ VAS scores (β = - 4.882; 95% CI - 5.579, - 4.184) compared to those without OAB. This disutility exceeded the minimally important difference. HRQoL declined progressively with increasing OAB severity, with the most pronounced impact observed in the 65-69-year age group. Urgency and urgency urinary incontinence showed the strongest negative relationships with HRQoL. The self-care dimension was most affected (OR 2.457; 95% CI 2.115, 2.853).

conclusionOAB is prevalent among community-dwelling older Japanese adults and is associated with clinically meaningful HRQoL reductions. These findings suggest the importance of early detection and severity-based, symptom-specific management, particularly targeting urgency and incontinence (e.g., β3-stimulants, behavioral therapy).

Indexed as

Health StatusQuality of LifeUrinary Bladder, OveractiveAgedAged, 80 and overCohort StudiesCross-Sectional StudiesFemaleHumansIndependent LivingJapanMaleSeverity of Illness IndexSurveys and QuestionnairesEQ-5D-5LEQ VASHealth-related quality of lifeOveractive bladder

Identifiers

PMID42260041

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.