Evidence map›Paper›PMID 42259910›Full record

ReviewCommunications biology2026

The signaling and regulatory functions of dying cells and cell corpses.

Guolin Zhang, Jinming Liu, Wenhui Li, Boya Wang, Haoxuan Feng, Tongzhou Cui, Taowen Pan, Dapeng Chen, Yongjian Xiong

Abstract readReview
In one paragraph

Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guolin Zhang *Central Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Jinming Liu *Central Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Wenhui Li *Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian, China.
Boya Wang *Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, China.
Haoxuan FengComparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian, China.
Tongzhou CuiComparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian, China.
Taowen PanInstitute (College) of Integrative Medicine, Dalian Medical University, Dalian, China. pantw@dmu.edu.cn.ORCID 0000-0001-6744-4210
Dapeng ChenCentral Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, China. friendchen@dmu.edu.cn.ORCID 0000-0001-9838-1646
Yongjian XiongCentral Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, China. private007@126.com.ORCID 0009-0007-7268-1895

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cells die extensively each day under physiological and pathological conditions, yet dying cells and cell corpses are not merely passive endpoints. Increasing evidence shows that they actively shape their microenvironment during death-program execution, signal release or exposure, corpse processing, and responses of neighboring cells and phagocytes. We here summarize six major roles of dying cells and cell corpses: promoting tissue turnover and remodeling, supporting neighboring-cell survival, mediating intercellular communication, providing metabolic substrates and rewiring phagocyte metabolism, facilitating corpse recognition and clearance, and modulating immune responses. Overall, they provide a broader framework for understanding cell death and identifying therapeutic opportunities.

Indexed as

ApoptosisCell DeathSignal TransductionAnimalsCell CommunicationHumansPhagocytes

Identifiers

PMID42259910
PMCPMC13247065

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.