Evidence map›Paper›PMID 42259860›Full record

ArticleScientific reports2026

Effect of smoking on vitamin D status in the adults of Henan, China: the role of HDL-C and LDL-C.

Baowei Wang, Guojie Wang, Li Gao, Guojun Yang, Shixian Feng, Jiying Xu

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Baowei WangPublic Health School, Henan Medical College, Zhengzhou, Henan, China.
Guojie WangPublic Health School, Henan Medical College, Zhengzhou, Henan, China. 2017050021@hamc.edu.cn.
Li GaoHenan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan, China.
Guojun YangPublic Health School, Henan Medical College, Zhengzhou, Henan, China.
Shixian FengHenan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan, China. fengsx@hncdc.com.cn.
Jiying XuHenan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Smoking has been reported to be associated with vitamin D (VD) status, but the evidence is limited. A cross-sectional study was conducted aiming to examine whether there is any effect of smoking on VD status in the adults based on the data sourced from the chronic diseases and nutrition surveillance in Henan. Multiple linear and multinomial logistic regression models based on the sampling design and weight were created to estimate the association between smoking and serum 25-hydroxyvitamin D concentration (S_25(OH)D_C) and VD status, respectively. It was found that in men, smokers had significantly lower S_25(OH)D_C and higher proportions of VD deficiency (VDD) and VD insufficiency (VDI) than non-smokers (S_25(OH)D_C: 18.2 ng/ml vs 19.8 ng/ml; proportion of VDD: 17.3% vs 14.3%; proportion of VDI: 44.7% vs 38.3%). Multivariate regression analyses demonstrated that in men smoking was independently associated with S_25(OH)D_C and VD status, reducing S_25(OH)D_C by 1.90 ng/ml, and increasing the risk of VDD and VDI by 134% and 65%, respectively. Further analysis stratified by the levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) revealed that in men with low HDL-C and high LDL-C, smoking increased 8.24 and 4.08 times likely to having VDD and VDI, respectively. In conclusion, smoking reduced S_25(OH)D_C, and increased the risk of VDD and VDI in men, especially in men with low level of HDL-C and high level of LDL-C in Henan.

Indexed as

Cholesterol, HDLCholesterol, LDLSmokingVitamin DVitamin D DeficiencyAdultChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk Factors25-hydroxyvitamin DCholesterol, HDLCholesterol, LDLVitamin D25-hydroxyvitamin DAssociationHDL-CLDL-CRisk factorSmokingVitamin D

Identifiers

PMID42259860
PMCPMC13490361

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