Evidence map›Paper›PMID 42259822›Full record

ArticleScientific reports2026

Organ at risk sparing by non-coplanar prone breast radiotherapy on Halcyon/Ethos linacs utilizing breast couch slewing.

Bruno Speleers, Michael E J Stouthandel, Vincent Vakaet, Leen Paelinck, Max Schoepen, Annick Van Greveling, Ann Van Esch, Anne-Catherine Wéra, Vincent Remouchamps, Tom Van Hoof and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bruno Speleers *Department of Human Structure and Repair, Ghent University, C. Heymanslaan 10, Radiotherapy park, entrance 98, B-9000, Ghent, Belgium.
Michael E J Stouthandel *Department of Human Structure and Repair, Ghent University, C. Heymanslaan 10, Radiotherapy park, entrance 98, B-9000, Ghent, Belgium. Michael.stouthandel@ugent.be.
Vincent VakaetDepartment of Human Structure and Repair, Ghent University, C. Heymanslaan 10, Radiotherapy park, entrance 98, B-9000, Ghent, Belgium.
Leen PaelinckDepartment of Radiation Oncology, Ghent University Hospital, C. Heymanslaan 10, Radiotherapy park, entrance 98, B-9000, Ghent, Belgium.
Max SchoepenHydraulic engineering laboratory, Flanders Hydraulics, Berchemlei 115, B-2140, Antwerp, Belgium.
Annick Van GrevelingDepartment of Radiation Oncology, Ghent University Hospital, C. Heymanslaan 10, Radiotherapy park, entrance 98, B-9000, Ghent, Belgium.
Ann Van Esch7Sigma Radiotherapy Physics, Kasteeldreef 2, B-1350, Tildonk, Belgium.
Anne-Catherine WéraDepartment of Radiotherapy, CHU-UCL Namur, Site Ste Elisabeth, Place Louise Godin 15, B-5000, Namur, Belgium.
Vincent RemouchampsDepartment of Radiotherapy, CHU-UCL Namur, Site Ste Elisabeth, Place Louise Godin 15, B-5000, Namur, Belgium.
Tom Van HoofDepartment of Human Structure and Repair, Ghent University, C. Heymanslaan 10, Radiotherapy park, entrance 98, B-9000, Ghent, Belgium.
Liv VeldemanDepartment of Human Structure and Repair, Ghent University, C. Heymanslaan 10, Radiotherapy park, entrance 98, B-9000, Ghent, Belgium.
Werner De GersemDepartment of Human Structure and Repair, Ghent University, C. Heymanslaan 10, Radiotherapy park, entrance 98, B-9000, Ghent, Belgium.
Wilfried De NeveDepartment of Human Structure and Repair, Ghent University, C. Heymanslaan 10, Radiotherapy park, entrance 98, B-9000, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organ at risk (OAR)-dose reductions are needed to minimize radiation toxicity in settings with high OAR-doses, like adjuvant breast and lymph node radiotherapy. Non-coplanar techniques, combined with prone positioning and deep inspiration breath hold (DIBH) techniques, could accomplish this. A planning study was performed in patients requiring left-side adjuvant breast and axillary/periclavicular lymph node irradiation (n = 8). Simulation was performed in prone crawl position using DIBH. Coplanar and non-coplanar short-arc VMAT plans were compared. Non-coplanar plans featured ≤ 20° angular separation between planes. Feasibility was tested using a CAD model, including a prone crawl breast couch positioned in an up to 20° angle (transverse plane) with the couchtop. Non-coplanar techniques can further reduce radiation exposure. Adding beams in planes with ± 15° to ± 20° angular separation with the transverse plane yielded > 20% mean-dose reductions simultaneously to heart, lungs and esophagus, compared to coplanar plans. Plans with ≤ ± 20° angular separation with the transverse plane proved feasible on linacs lacking couch isocenter rotations. Angular separation of ± 15° seems the best compromise between OAR-sparing and technical challenges. Non-coplanar radiotherapy options yielded superior OAR sparing compared to coplanar techniques in patients requiring adjuvant breast and lymph node irradiation and should be considered for improved radiation toxicity prevention.

Indexed as

Breast NeoplasmsOrgans at RiskOrgan Sparing TreatmentsRadiotherapy Planning, Computer-AssistedBreath HoldingFemaleHumansProne PositionRadiotherapy DosageRadiotherapy, Intensity-ModulatedBreast cancerDeep inspiration breath holdOrgan at risk sparingProne positionRadiotherapyTreatment planning

Identifiers

PMID42259822
PMCPMC13490613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.