Evidence map›Paper›PMID 42259793›Full record

ArticleNature communications2026

Design and evolution of the tetracycline repressor into sulfonylurea herbicide-responsive gene switches for field crops.

Kevin E McBride, Naga Kishore Kakani, Nina G Bozhanova, Jin Fang, Keith Lowe, Christopher Leija, Brian McGonigle, Eric R Schreiter, Flynn Hermanson, Mandy Chan and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Kevin E McBride *Research and Development, Corteva Agriscience, Johnston, IA, USA. kmcswitch@gmail.com.ORCID http://orcid.org/0009-0000-1320-6356
Naga Kishore Kakani *Research and Development, Corteva Agriscience, Johnston, IA, USA.
Nina G Bozhanova *Department of Neurosciences, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-2164-5698
Jin FangResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Keith LoweResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Christopher LeijaResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Brian McGonigleResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Eric R SchreiterHoward Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-2864-7469
Flynn HermansonResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Mandy ChanResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Maren ArlingResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Ning WangResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Hyeon-Je ChoResearch and Development, Corteva Agriscience, Johnston, IA, USA.ORCID http://orcid.org/0000-0002-3399-7420
Christian RicheyResearch and Development, Corteva Agriscience, Johnston, IA, USA.
George HoersterResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Jonathan S MarvinHoward Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA.ORCID http://orcid.org/0000-0003-2294-4515
Brian LendertsResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Maxwell R McReynoldsResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Craig HastingsResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Alfredo MadrigalResearch and Development, Corteva Agriscience, Johnston, IA, USA.
S Carl FalcoResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Michael W LassnerResearch and Development, Corteva Agriscience, Johnston, IA, USA.
Ajith AnandResearch and Development, Corteva Agriscience, Johnston, IA, USA.
William Gordon-KammResearch and Development, Corteva Agriscience, Johnston, IA, USA. william.gordon-kamm@corteva.com.ORCID http://orcid.org/0000-0002-4852-751X
Loren L LoogerDepartment of Neurosciences, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA, USA. llooger@ucsd.edu.ORCID http://orcid.org/0000-0002-7531-1757

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
NCI NIH HHS P30 CA023100NIGMS NIH HHS P30 GM124169
6 · The paper itself

Abstract

Chemically inducible expression systems enable transgene expression regulation in response to external small molecules. Tetracycline repressor (TetR)-based gene switches work in plants, but antibiotics are neither approved nor advisable for crop use. Here we report engineering of TetR mutants that respond to approved sulfonylurea (SU) herbicides instead of antibiotics. Designed variants show low-nanomolar EC

Indexed as

Crops, AgriculturalGene Expression Regulation, PlantHerbicidesRepressor ProteinsSulfonylurea CompoundsArabidopsisNicotianaOryzaPlants, Genetically ModifiedZea maysHerbicidesRepressor ProteinsSulfonylurea Compoundstetracycline resistance-encoding transposon repressor protein

Identifiers

PMID42259793
PMCPMC13402354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.