ArticleAngewandte Chemie (International ed. in English)2026
A Self-Cascade Nanozyme of Metformin-Stabilized Amorphous Iron Oxide With Ultrahigh Fe(II) for Potent Tumor Therapy at Ultralow Dose.
Wanxuan Xiang, Xiaoju Yang, Yuchun Liu, Beibei Tian, Wenting Wang, Min Zhou, Zhiqiang Lin, Xuan Yang, Hongping Zhou, Xiaojiao Zhu
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In one paragraphArticle in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
10 authors.
Wanxuan XiangDepartment of Chemistry, School of Chemistry and Chemical Engineering, Centre of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei, P. R. China.
Xiaoju YangDepartment of Chemistry, Key Laboratory of Material Chemistry for Energy Conversion and Storage, Huazhong University of Science and Technology, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, P. R. China.
Yuchun LiuHefei National Research Center for Physical Sciences at the Microscale, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Beibei TianDepartment of Chemistry, School of Chemistry and Chemical Engineering, Centre of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei, P. R. China.
Wenting WangDepartment of Chemistry, School of Chemistry and Chemical Engineering, Centre of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei, P. R. China.
Min ZhouHefei National Research Center for Physical Sciences at the Microscale, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui, P. R. China.ORCID 0000-0003-2677-5472 Zhiqiang LinInstitute of Systems Biomedicine, Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.ORCID 0000-0003-1834-2060 Xuan YangDepartment of Chemistry, Key Laboratory of Material Chemistry for Energy Conversion and Storage, Huazhong University of Science and Technology, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, P. R. China.ORCID 0000-0001-8750-0742 Hongping ZhouDepartment of Chemistry, School of Chemistry and Chemical Engineering, Centre of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei, P. R. China.ORCID 0000-0001-9583-2595 Xiaojiao ZhuDepartment of Chemistry, School of Chemistry and Chemical Engineering, Centre of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei, P. R. China.ORCID 0000-0002-8128-9402 Funding
Beijing Natural Science Foundation L242055HUST Academic Frontier Youth Team grant 2019QYTD11Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education Anhui University JF202512010001National Natural Science Foundation of China 22204054National Natural Science Foundation of China 22375003National Natural Science Foundation of China 22422405National Natural Science Foundation of China 52170031National Natural Science Foundation of China 52372073University Annual Scientific Research Plan of Anhui Province 2023AH050064
6 · The paper itselfAbstract
The therapeutic efficacy of iron oxide nanozymes in cancer catalytic therapy has been severely constrained by the insufficient endogenous H
Indexed as
Antineoplastic AgentsFerric CompoundsFerrous CompoundsMetforminAnimalsCell Line, TumorHumansHydrogen PeroxideMiceAntineoplastic AgentsFerric Compoundsferric oxideFerrous CompoundsHydrogen PeroxideMetforminamorphousself–cascade nanozymetumor therapyultrahigh Fe (II)
Identifiers
PMID42259619
PMCPMC13452565
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