Evidence map›Paper›PMID 42259288›Full record

ArticleNeuron2026

Prefrontal gamma oscillations engage dynamic cell-type-specific configurations to support flexible behavior.

Aarron Justin Phensy, Lara Louise Hagopian, Caitriona Min-Yi Costello, Simon Haziza, Omkar Ghenand, Jingcheng Shi, Yanping Zhang, Mark J Schnitzer, Vikaas Singh Sohal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Aarron Justin PhensyDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0444, USA.
Lara Louise HagopianDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0444, USA.
Caitriona Min-Yi CostelloDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0444, USA.
Simon HazizaJames H. Clark Center, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA.
Omkar GhenandDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0444, USA.
Jingcheng ShiDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0444, USA.
Yanping ZhangJames H. Clark Center, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Mark J SchnitzerJames H. Clark Center, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Vikaas Singh SohalDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0444, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0444, USA. Electronic address: vikaas.sohal@ucsf.edu.

Funding

Multi-color optical voltage imaging of neural activity in behaving animalsU01NS120822 · NINDS · STANFORD UNIVERSITY · PI SCHNITZER, MARK J, VASAN, GANESH · 2021 to 2025
$3.3M
Dissecting neocortical field potential dynamics using optical voltage imaging in genetically targeted cell-typesR01NS124590 · NINDS · STANFORD UNIVERSITY · PI MARK J SCHNITZER, IVAN SOLTESZ · 2021 to 2026
$3.1M
Neurodevelopmental defects of the thalamocortical pathway as a convergent feature of psychiatric disordersR01MH128364 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Tomasz Nowakowski, JOHN L. R. RUBENSTEIN · 2023 to 2026
$3.0M
Improving cognition by understanding and harnessing the plasticity of gamma-generating circuits in prefrontal cortexR01MH129835 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Vikaas Singh Sohal · 2022 to 2026
$2.7M
How is anxiety-related information relayed across hippocampal-prefrontal circuitsR01MH117961 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A, SOHAL, VIKAAS SINGH · 2019 to 2022
$2.3M
How do parvalbumin interneuron-generated gamma oscillations organize prefrontal networks to promote behavioral adaptation?R01NS116594 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOHAL, VIKAAS SINGH · 2020 to 2024
$2.2M
Using new methods for voltage imaging to assay the engagement of specific cell-types and brain rhythms in prefrontal-dependent cognition.R01MH121342 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOHAL, VIKAAS SINGH · 2019 to 2022
$1.7M
How is anxiety-related information relayed across hippocampal-prefrontal circuitsR56MH117961 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A, SOHAL, VIKAAS SINGH · 2018 to 2018
$689k
NIMH NIH HHS R01 MH117961NIMH NIH HHS R01 MH121342NIMH NIH HHS R01 MH128364NIMH NIH HHS R01 MH129835NIMH NIH HHS R56 MH117961NINDS NIH HHS R01 NS116594NINDS NIH HHS R01 NS124590NINDS NIH HHS U01 NS120822
6 · The paper itself

Abstract

Cognitive dysfunction in conditions such as schizophrenia involves disrupted communication between the prefrontal cortex (PFC) and the mediodorsal thalamus (MD). Parvalbumin interneurons (PVIs) are known to regulate PFC microcircuits and generate synchronized gamma-frequency (∼40 Hz) neural oscillations that are recruited during many executive functions, necessary for cognitive flexibility, and deficient in schizophrenia. While targeting PVI-mediated gamma oscillations holds great therapeutic promise, their nature and specific functions, e.g., for regulating PFC→MD communication, remain elusive. Using dual-color voltage indicators and optogenetics in mice, we reveal that PVIs dynamically synchronize with MD-projecting PFC neurons both locally and contralaterally, creating multiple distinct circuit-specific patterns of distributed gamma synchronization that are recruited in a behaviorally specific manner to support particular aspects of flexible behavior. Thus, gamma oscillations are not unitary phenomena characterized by one microcircuit-wide pattern of synchrony. Rather, they comprise diverse motifs, defined by specific cell types and phase relationships, that are dynamically recruited for specific functions.

Indexed as

cognitive flexibilitygamma oscillationsmediodorsal thalamusparvalbumin interneuronsprefrontal cortex

Identifiers

PMID42259288
PMCPMC13359335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.