Trial reportESMO open2026
Scalp cooling outcomes in patients receiving trastuzumab deruxtecan for metastatic breast cancer.
Trial report in ESMO open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
18 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTrastuzumab deruxtecan (T-DXd) has improved outcomes for many patients with metastatic breast cancer (MBC). T-DXd is associated with alopecia, yet limited data exist describing the efficacy of scalp cooling (SC) in preventing alopecia among patients receiving T-DXd. PATIENTS AND
methodsThis prospective, phase II trial evaluated the efficacy of SC among patients with MBC receiving T-DXd. Conducted at Dana-Farber Cancer Institute, the trial enrolled patients with MBC without alopecia at baseline, initiating treatment with T-DXd. Participants elected either the SC arm, using the Paxman Scalp Cooling System, or the non-SC arm. The primary endpoint was hair loss rate, defined as locally assessed Common Terminology Criteria for Adverse Events (version 5.0) grade ≥1 alopecia occurring at cycle 3, day 1; cycle 5, day 1; or end of treatment, whichever occurred first.
resultsAmong 40 enrolled evaluable patients, 33 (82.5%) patients [18 (90%) in the SC arm and 15 (75%) in the non-SC arm] experienced grade ≥1 alopecia. The difference in rates between arms was not statistically significant (P = 0.41). Grade 2 alopecia rates were the same in both arms (55%). Centralized image review revealed no significant differences in grade ≥1 (P = 1.00) or grade 2 alopecia (P = 0.33) between treatment arms. Grade 2 alopecia was the primary reason for SC discontinuation (45%). The median time to grade 2 alopecia was 2.76 months [95% confidence interval (CI), 1.64-NA] in the SC arm; 4.60 months (95% CI, 2.53-NA) in the non-SC arm (P = 0.7).
conclusionsSC with T-DXd did not reduce alopecia rates. Small sample size and lack of randomization may have limited the interpretation. Further studies are crucial to improve SC's efficacy with antibody-drug conjugate therapy.
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