Open bite malocclusion and orofacial dysfunction in patients with rare diseases.

Christina Havner, Åsa Mogren, Lotta Sjögreen, Anna Westerlund

Abstract readComparative Study

In one paragraph

Article in European journal of orthodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Christina HavnerDepartment of Orthodontics, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, PO Box 450, Gothenburg SE-405 30, Sweden.ORCID 0000-0003-2910-026X

Åsa MogrenMun-H-Center, Orofacial Resource Center for Rare Diseases, Public Dental Service, Vastra Gotalandsregionen, PO Box 7163 SE-402 33, Gothenburg, Sweden.ORCID 0000-0002-0472-1783

Lotta SjögreenMun-H-Center, Orofacial Resource Center for Rare Diseases, Public Dental Service, Vastra Gotalandsregionen, PO Box 7163 SE-402 33, Gothenburg, Sweden.

Anna WesterlundDepartment of Orthodontics, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, PO Box 450, Gothenburg SE-405 30, Sweden.ORCID 0000-0003-2438-8516

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo compare orofacial dysfunctions (OFD) in individuals with rare diseases, with and without open bite (OB) malocclusion, and to explore the associated symptoms. PATIENTS AND

methodsIn total, data for 788 individuals representing 164 different rare diseases, were collected from the MHC database for the period of 2013-2019. The inclusion criteria were having a rare disease and having completed the Nordic Orofacial Test-Screening (NOT-S). OB was categorized as anterior OB (AOB), lateral OB (LOB), and severe anterior OB (AOBS). The sample was divided into two groups: 142 with OB (mean age, 14.2 ± 13.0 years; 81 males, 61 females); and 557 with normal vertical relation (NVR) (mean age, 15.1 ± 12.9 years; 292 males, 265 females). OFD was compared between the groups. Items from the NOT-S test were analysed, and the Odds Ratio (OR) for OB was calculated.

resultsThe OB prevalence was 18%, with AOB being the most-common sub-type (58%), followed by AOBS (15%) and LOB (13%). Nemaline myopathy was the disease with the highest prevalence rates for OB and AOBS. The OB group had a larger proportion of OFD than the NVR group in 6/12 domains of the NOT-S. Deviant tongue posture was most strongly associated with OB (OR 6.062).

conclusionTwo-thirds of the individuals had OFD, and OB was a common finding (18%). Rare diseases with symptoms of orofacial hypotonia, craniofacial abnormalities and macroglossia show a higher prevalence of OB. A deviant tongue posture showed the highest odds for OB in this group of rare diseases.

Indexed as

Open BiteRare DiseasesAdolescentChildFemaleHumansMalePrevalenceYoung Adultcraniofacial abnormalitiesmacroglossiamuscular hypotonianeuromuscular diseasesopen biteorthodonticsrare diseases

Identifiers

PMID42258833

DOI10.1093/ejo/cjag037

PMCPMC13244795

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