ArticleProceedings (Baylor University. Medical Center)2026
Association of polypharmacy and medication class diversity with postoperative complications following operative ankle fracture repair.
Article in Proceedings (Baylor University. Medical Center), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Beyond comorbidity scores: medication burden as a window into surgical risk following ankle fracture fixation.Proceedings (Baylor University. Medical Center) · 2026Article
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6 authors.
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Abstract
backgroundPolypharmacy is increasingly common and may influence outcomes following orthopedic trauma. While specific medication classes have been associated with complications in arthroplasty and spine surgery, the role of total preoperative medication count in ankle trauma remains unclear. This study evaluated whether polypharmacy and medication class diversity were independently associated with postoperative complications after operative ankle fracture repair.
methodsA retrospective cohort study included 178 adult patients who underwent operative fixation of ankle fractures at a single academic medical center. Preoperative medication burden was assessed using total outpatient medication count and medication class diversity. Postoperative outcomes included deep vein thrombosis (DVT), surgical site infection, nonunion, malunion, and surgical revision. Multivariable logistic regression models were constructed for each medication exposure, adjusting for age, sex, Charlson Comorbidity Index, American Society of Anesthesiologists class, and smoking status.
resultsPolypharmacy was independently associated with postoperative DVT (
conclusionsPreoperative medication burden may be associated with postoperative complications after ankle fracture repair. Medication class diversity shows broader associative utility and may serve as a useful adjunct to risk stratification.
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