Evidence map›Paper›PMID 42258635›Full record

ArticleThe Journal of clinical endocrinology and metabolism2026

Classification of glucose profile in Japanese patients with type 1 diabetes and its association with complications.

Takafumi Masuda, Naoto Katakami, Naohiro Taya, Kazuyuki Miyashita, Mitsuyoshi Takahara, Ken Kato, Iichiro Shimomura

Abstract read
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Takafumi MasudaDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Naoto KatakamiDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.ORCID 0000-0001-9020-8320
Naohiro TayaDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Kazuyuki MiyashitaDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Mitsuyoshi TakaharaDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.
Ken KatoDiabetes Center, NHO Osaka National Hospital, Chuo-ku, Osaka City, Osaka 540-0006, Japan.
Iichiro ShimomuraDepartment of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan.ORCID 0000-0002-0851-9603

Funding

Japan Association for Diabetes Education and CareJapan IDDM network
6 · The paper itself

Abstract

contextThe importance of utilizing continuous glucose monitoring (CGM) to optimize glycemic profiles and thereby prevent the onset of diabetic complications in patients with type 1 diabetes has been increasingly recognized. Nevertheless, studies evaluating the risk of diabetic complications in patients with type 1 diabetes through machine learning approaches based on CGM data remain limited.

objectiveTo classify the glycemic profiles of Japanese patients with type 1 diabetes using a data-driven cluster analysis based on CGM and clarify the association between these clusters and diabetic complications.

methodsIn this cross-sectional study, a cluster analysis using glycemic metrics from CGM of 153 Japanese patients with type 1 diabetes was performed. Logistic regression analysis adjusted for age, sex, and duration of diabetes was performed to compare the risk of diabetic complications by cluster.

resultsThe cluster analysis identified four clusters. Cluster 1 (n = 53) exhibited an optimal glycemic profile. Cluster 2 (n = 46) demonstrated an extended duration of hyperglycemia and a higher risk of elevated brachial-ankle pulse wave velocity than Cluster 1. Cluster 3 (n = 39) demonstrated an extended duration of hypoglycemia and a higher risk of severe hypoglycemia than Cluster 1. Cluster 4 (n = 15) demonstrated large glycemic variability associated with hyperglycemia and hypoglycemia. Cluster 4 had higher risks of polyneuropathy, elevated brachial-ankle pulse wave velocity, and higher cardiovascular disease risk scores than Cluster 1.

conclusionHigh-risk diabetic complications were identified for each cluster classified by glycemic profile.

Indexed as

Blood GlucoseDiabetes ComplicationsDiabetes Mellitus, Type 1HyperglycemiaAdultCluster AnalysisClustering AlgorithmsContinuous Glucose MonitoringCross-Sectional StudiesEast Asian PeopleFemaleHumansHypoglycemiaJapanMaleMiddle AgedBlood Glucoseatherosclerosiscluster analysiscontinuous glucose monitoringmicroangiopathytype 1 diabetes

Identifiers

PMID42258635
PMCPMC13671772

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.