Evidence map›Paper›PMID 42258395›Full record

ArticleeLife2026

Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling.

Kasturi Biswas, Caroline Moore, Hannah Rogers, Khursheed A Wani, Arjamand Mushtaq, Read Pukkila-Worley, Daniel P Higgins, Amy K Walker, Gregory P Mullen, James B Rand and 1 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kasturi BiswasDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.ORCID https://orcid.org/0000-0001-7243-1422
Caroline MooreDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.ORCID https://orcid.org/0000-0002-1099-5721
Hannah RogersDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.
Khursheed A WaniDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, United States.ORCID https://orcid.org/0000-0003-3559-7962
Arjamand MushtaqProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, United States.
Read Pukkila-WorleyDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, United States.ORCID https://orcid.org/0000-0001-5340-8294
Daniel P HigginsProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, United States.
Amy K WalkerProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, United States.ORCID https://orcid.org/0000-0003-1899-8916
Gregory P MullenGenetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, United States.
James B RandGenetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, United States.
Michael M FrancisDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.ORCID https://orcid.org/0000-0002-8076-6668

Funding

Molecular Analysis of Neural Circuit Excitation and InhibitionR01NS064263 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FRANCIS, MICHAEL M · 2009 to 2025
$5.5M
Dual transcriptional programs coordinate lipogenic and membrane stress responsive programs in C. elegans - SupplementR01AG068670 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WALKER, AMY KAROL · 2021 to 2025
$2.1M
National Science Foundation 1755019NIA NIH HHS R01AG068670NINDS NIH HHS R01NS064263
6 · The paper itself

Abstract

Organisms have evolved protective strategies that are geared toward limiting cellular damage and enhancing organismal survival in the face of environmental stresses, but how these protective mechanisms are coordinated remains unclear. Here, we define a requirement for neural activity in mobilizing the antioxidant defenses of the nematode

Indexed as

AcetylcholineCaenorhabditis elegansCaenorhabditis elegans ProteinsOxidative StressReceptors, G-Protein-CoupledReceptors, MuscarinicSignal TransductionTranscription, GeneticAnimalsAcetylcholineCaenorhabditis elegans ProteinsGAR-3 protein, C elegansReceptors, G-Protein-CoupledReceptors, MuscarinicC. elegansgeneticsgenomicsmuscarinic acetylcholine receptorneuroscienceoxidative stressproteostasisreactive oxygen speciestranscriptomics

Identifiers

PMID42258395
PMCPMC13246005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.