Evidence map›Paper›PMID 42258375›Full record

ArticleeLife2026

Uncoupling the TFIIH Core and Kinase Modules leads to misregulated RNA polymerase II CTD Serine 5 phosphorylation.

Gabriela Giordano, Robin Buratowski, Célia Jeronimo, Christian Poitras, François Robert, Stephen Buratowski

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Gabriela GiordanoDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0009-0002-8068-9487
Robin BuratowskiDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.
Célia JeronimoInstitut de recherches cliniques de Montréal (IRCM), Montréal, Canada.ORCID https://orcid.org/0000-0002-3190-5211
Christian PoitrasInstitut de recherches cliniques de Montréal (IRCM), Montréal, Canada.ORCID https://orcid.org/0000-0001-6444-7600
François RobertInstitut de recherches cliniques de Montréal (IRCM), Montréal, Canada.ORCID https://orcid.org/0000-0003-1054-5920
Stephen BuratowskiDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0003-0440-3926

Funding

The RNA Polymerase II Transcription CycleR01GM056663 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Stephen Buratowski · 1999 to 2026
$11.7M
The RNA polymerase II transcription complexR01GM046498 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BURATOWSKI, STEPHEN · 1996 to 2024
$9.4M
CIHR PJT-162334NIGMS NIH HHS GM046498NIGMS NIH HHS GM056663NIGMS NIH HHS R01 GM046498NIGMS NIH HHS R01 GM056663
6 · The paper itself

Abstract

TFIIH is an essential transcription initiation factor for RNA polymerase II (RNApII). This multi-subunit complex comprises two modules that are physically linked in

Indexed as

RNA Polymerase IISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSerineTranscription Factor TFIIHPhosphorylationRNA Polymerase IISaccharomyces cerevisiae ProteinsSerineTranscription Factor TFIIHCDK7/Kin28chromosomesCTD phosphorylationgene expressionMAT1/Tfb3RNA polymerase IIS. cerevisiaeTFIIH

Identifiers

PMID42258375
PMCPMC13246002

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.