ArticleAmerican journal of physiology. Renal physiology2026
Sex differences in the renal T cell profile in DOCA-salt hypertension are independent of MR activation and increases in blood pressure.
Article in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We previously reported that T cells contribute to sex differences in blood pressure (BP) in deoxycorticosterone acetate (DOCA)-salt hypertension, yet the mechanism(s) modulating T-cell activation are still being investigated. The goal of the current study was to determine the relative contribution of mineralocorticoid receptor (MR) activation versus increases in BP to changes in the renal T cell profile in male and female DOCA-salt rats. Ten-week-old uninephrectomized male and female Sprague Dawley rats were implanted with a subcutaneous 21-day slow-release DOCA pellet (200 mg). To assess the relative contribution of MR activation versus the development of hypertension, subsets of male and female DOCA rats were randomized to
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