ArticleACS chemical biology2026
SENSIT, a Modular Single-Chain Fluorescent Integrator Platform for GPCR Ligands.
Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
G-protein-coupled receptors (GPCRs) transduce the effects of many neurotransmitters such as epinephrine, norepinephrine, and acetylcholine. However, understanding neurotransmitter release via GPCRs at high resolution across large brain volumes remains a significant challenge. Here, we report a modular platform called single-chain expressing neurotransmitter sensing integrator tool (SENSIT) featuring the design of bifunctional chimeric nanobodies. We applied the SENSIT platform by designing reporters for epinephrine and norepinephrine that exhibit 20-fold and 5-fold selectivity over another catecholamine, respectively. To further demonstrate the modularity of the platform, we also developed a muscarinic acetylcholine receptor 2 (CHRM2)-based sensor and chimeric miniG proteins. The SENSIT platform reports the first single-chain integrator sensor capable of distinguishing epinephrine and norepinephrine as well as enabling the generalized design of integrator sensors for diverse neurotransmitters with the potential for whole-brain mapping.
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