Evidence map›Paper›PMID 42258131›Full record

ArticleScience China. Life sciences2026

KLF6 regulates osteoclastogenesis through DUSP16 in OVX-induced bone loss.

Chen Yang, Wei Zhang, Xin Liu, Wenming Li, Yi Qin, Wenhao Li, Zebin Wu, Kunlong Jiang, Chenglong Wang, Zhonglai Qian and 2 more

Abstract read
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In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chen Yang *Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Wei Zhang *Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Xin Liu *Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Wenming LiDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Yi QinDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Wenhao LiDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Zebin WuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Kunlong JiangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Chenglong WangDepartment of Orthopedic Surgery, XinHua Hospital Affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, 200082, China. wangchenglong@xinhuamed.com.cn.
Zhonglai QianDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. szqzlspine@163.com.
Liangliang WangDepartment of Orthopaedics, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213003, China. liangliangwang@njmu.edu.cn.
Dechun GengDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. szgengdc@suda.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estrogen deficiency results in enhanced bone resorption by osteoclasts, a critical factor in the development of postmenopausal osteoporosis. This study investigates the regulatory role of KLF6 in osteoclast differentiation and evaluates its potential in reducing bone loss in ovariectomized (OVX) mice. The results show that the expression of KLF6 gradually decreases during osteoclast differentiation, and this decrease is more pronounced in the OVX model. Reducing the expression level of KLF6 can promote the differentiation of osteoclasts. Through RNA sequencing and ChIP analysis, we found that KLF6 inhibits the activity of the MAPK signaling pathway by upregulating the expression of DUSP16, thereby suppressing osteoclast differentiation. In vivo experiments demonstrate that overexpression of KLF6 via adeno-associated virus can reduce OVX-induced bone loss, suggesting that KLF6 may serve as a potential therapeutic target for bone loss caused by estrogen deficiency.

Indexed as

DUSP16KLF6osteoclastovariectomizedpostmenopausal osteoporosis

Identifiers

PMID42258131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.