Evidence map›Paper›PMID 42258129›Full record

ArticleScience China. Life sciences2026

The nucleosome assembly protein Nap1 regulates chromatin stability and nuclear division in Tetrahymena thermophila.

Sitong Yang, Jin Mi, Jing Xu, Wei Wang

Abstract read
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Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sitong YangKey Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, 030006, China.
Jin MiKey Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, 030006, China.
Jing XuKey Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, 030006, China. xujing@sxu.edu.cn.
Wei WangKey Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, 030006, China. gene@sxu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromatin stability is essential for maintaining genome integrity and gene regulation in eukaryotic cells. Nucleosome assembly protein 1 (Nap1) is a key regulator of chromatin dynamics across different organisms. The ciliate Tetrahymena thermophila contains two functionally distinct nuclei within a single cell: the diploid germline micronucleus (MIC), which undergoes mitosis and meiosis, and the polyploid somatic macronucleus (MAC), which divides amitotically. However, the function of Nap1 in this evolutionarily distant protist remains unclear. Here, we show that Nap1 localizes predominantly to the perinuclear region of the MAC during vegetative growth and is also detectable in the MAC, MIC, and cytoplasm. Truncation of the nuclear export signal (NES) increases accumulation of Nap1

Indexed as

Cell Nucleus DivisionChromatinNucleosome Assembly Protein 1Protozoan ProteinsTetrahymena thermophilaCell NucleusMacronucleusMicronucleus, GermlineChromatinNucleosome Assembly Protein 1Protozoan Proteinschromatin stabilityNap1nuclear divisionTetrahymena thermophila

Identifiers

PMID42258129

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.