Evidence map›Paper›PMID 42258100›Full record

ReviewVeterinary research communications2026

The multifaceted challenge of viral nervous necrosis in fish farming: a review of current knowledge and control.

Eman Zahran, Samia Elbahnaswy, Reham Karam, Noha I ElBanna, Mahmoud G El Sebaei

Abstract readReview
PubMed Publisher
In one paragraph

Review in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eman ZahranDepartment of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt. emanzahran@mans.edu.eg.ORCID http://orcid.org/0000-0003-2212-3688
Samia ElbahnaswyDepartment of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.ORCID http://orcid.org/0000-0003-1414-9407
Reham KaramVirology Department, Weqaa Center Central Laboratory, Riyadh, Saudi Arabia.
Noha I ElBannaAquaculture Diseases Control Department, Fish Farming & Technology Institute, Suez Canal University, Ismailia, 41522, Egypt.
Mahmoud G El SebaeiDepartment of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, 31982, Saudi Arabia.

Funding

The Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia Grant No. KFU260316.
6 · The paper itself

Abstract

Viral nervous necrosis (VNN), caused by the nervous necrosis virus (NNV) of the genus Betanodavirus, is a significant threat to global aquaculture, resulting in substantial economic losses in both marine and freshwater fish farming. The virus demonstrates considerable genetic diversity, encompassing multiple genotypes and reassortant strains that affect host susceptibility and disease severity across a wide array of fish species. Environmental factors strongly influence viral transmission and outbreak dynamics. Advances in diagnostic methodologies have enhanced the speed and sensitivity of detection. Although commercial vaccines are available for selected host species and production settings, their availability remains limited across fish species, viral genotypes, geographic regions, and early developmental stages. This review summarizes the current knowledge on Betanodavirus virology, host tropism, epidemiology, molecular diagnosis, microbiome, and control. Furthermore, it focuses on advanced disease manipulation via the microbiome and emerging molecular diagnostic platforms.

Indexed as

Fish DiseasesNodaviridaeRNA Virus InfectionsAnimalsAquacultureFishesControlFishMicrobiomeMolecular diagnosticsNervous necrosis virusNNVPathogenesisViral nervous necrosisVNN

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.