Evidence map›Paper›PMID 42258088›Full record

ArticleNeurochemical research2026

8-Gingerol Mitigates MPP

Ya-Chen Shih, Tzu-Yu Kuo, Ching Chang, Chia-Yuan Lin, Chun-Huei Liao, Yu-Jung Hsiao, Chia-Wen Tsai

Abstract read
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In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ya-Chen Shih *Department of Nutrition, China Medical University, Taichung, Taiwan.
Tzu-Yu Kuo *Department of Nutrition, China Medical University, Taichung, Taiwan.
Ching ChangDepartment of Nutrition, China Medical University, Taichung, Taiwan.
Chia-Yuan LinDepartment of Food Science, National Taiwan Ocean University, Keelung, Taiwan.
Chun-Huei LiaoDepartment of Nutrition, China Medical University, Taichung, Taiwan.
Yu-Jung HsiaoDepartment of Nutrition, China Medical University, Taichung, Taiwan.
Chia-Wen TsaiDepartment of Nutrition, China Medical University, Taichung, Taiwan. cwtsai@cmu.edu.tw.

Funding

China Medical University, Taiwan CMU112-S-12Ministry of Science and Technology, Taiwan MOST 109-2320-B-039-055
6 · The paper itself

Abstract

Impaired insulin signaling facilitates α-synuclein aggregation and exacerbates neuroinflammation related to Parkinson's disease (PD). This study investigated whether 8-gingerol from ginger could protect against MPP⁺-induced α-synuclein aggregation and neuroinflammation in SH-SY5Y cells via the insulin signaling pathway. MTT assay showed that MPP⁺ markedly reduced SH-SY5Y cell viability at 0.5-2 mM. Treatment of cells with 6-gingerol and 8-gingerol, but not 6-shogaol, significantly attenuated MPP⁺-induced cytotoxicity. The concentration at 20 µM showed the strongest neuroprotective effect. Immunoblots showed that 8-gingerol treatment attenuated the accumulation of

Indexed as

1-Methyl-4-phenylpyridiniumalpha-SynucleinCatecholsFatty AlcoholsInflammasomesInsulinNeuroprotective AgentsNLR Family, Pyrin Domain-Containing 3 ProteinSignal TransductionCell Line, TumorCell SurvivalHumans1-Methyl-4-phenylpyridiniumalpha-SynucleinCatecholsFatty AlcoholsgingerolInflammasomesInsulinNeuroprotective AgentsNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, human8-gingerolInsulin signaling pathwayMPP+NeuroinflammationParkinson's diseaseSH-SY5Y cells

Identifiers

PMID42258088

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.