Evidence map›Paper›PMID 42258014›Full record

ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2026

Investigating synergistic effects of key medium components and pectin elicitor on taxane fermentation in Neopestalotiopsis vitis: A Box-Behnken response surface methodology approach.

Hamzeh Rezazadeh, Sepideh Mirzaei Rad, Mojdeh Amandadi, Faezeh Ghanati, Saman Hosseinkhani

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Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Hamzeh RezazadehDepartment of Plant Biology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Sepideh Mirzaei RadDepartment of Plant Biology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Mojdeh AmandadiDepartment of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Faezeh GhanatiDepartment of Plant Biology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Saman HosseinkhaniDepartment of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. Saman_h@modares.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Taxanes are high-value diterpenoid compounds with potent anticancer activity, notably used in the treatment of breast and ovarian cancers. The newly isolated Iranian endophytic fungus Neopestalotiopsis vitis (N. vitis), recovered from native hazelnut (Corylus avellana) tissues, has demonstrated the ability to biosynthesize paclitaxel. However, maximizing its biotechnological potential requires a well-optimized culture system that accounts for synergistic interactions between nutritional factors and elicitor treatments. In this study, Response Surface Methodology (RSM) employing a Box-Behnken Design (BBD) was used to systematically investigate the individual and synergistic effects of four parameters-pH (4.0-8.0), malt extract (1.0-5.0 g L⁻¹), (NH₄)₂SO₄ (1.25-5.0 mM), and hazelnut-derived pectin (50-150 mg flask

Indexed as

BiomassFermentation optimizationNeopestalotiopsis vitisResponse surface methodologySynergistic interactionsTaxane

Identifiers

PMID42258014

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.