Evidence map›Paper›PMID 42257988›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026

Mepilex Lite dressing in the management of radiation dermatitis-a systematic review and meta-analysis of randomized controlled trials.

Henry C Y Wong, Britney Zhang, Shely Kagan, Christina Yang, Shirley S W Tse, Laura Tang, Caroline Hircock, Shing Fung Lee, Tarek Hijal, Amir H Safavi and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Henry C Y WongDepartment of Oncology, Princess Margaret Hospital, Kowloon West Cluster, Hospital Authority, Hong Kong SAR, China. henrywong3011@gmail.com.
Britney ZhangOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Shely KaganOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Christina YangOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Shirley S W TseDepartment of Clinical Oncology, Queen Elizabeth Hospital, Kowloon Central Cluster, Hospital Authority, Hong Kong S.A.R, Kowloon, China.
Laura TangTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Caroline HircockDepartment of Radiation Oncology, University of Toronto, Toronto, Canada.
Shing Fung LeeDepartment of Radiation Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore.
Tarek HijalDivision of Radiation Oncology, McGill University Health Centre, Montréal, QC, Canada.
Amir H SafaviOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Irene KaramOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Edward ChowOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRadiation dermatitis is a common side effect of radiation therapy, often affecting patient comfort and may lead to treatment interruption. This systematic review and meta-analysis aimed to evaluate the effectiveness of Mepilex Lite dressings compared to standard care in managing radiation dermatitis.

methodsFollowing PRISMA guidelines, a comprehensive search of Cochrane CENTRAL, CINAHL, Embase, and MEDLINE was conducted up to July 2025. Randomized controlled trials (RCTs) comparing Mepilex Lite to standard of care in patients undergoing radiation therapy were included. Primary outcomes included changes in dermatitis severity using validated grading systems. Secondary outcomes were time to wound healing, patient-reported symptoms, and quality of life. Meta-analyses were conducted using Revman, and risk of bias was assessed using the Cochrane Risk of Bias 2 tool.

resultsThree RCTs involving 186 patients were included. Two studies focused on breast cancer and one on nasopharyngeal cancer. Mepilex Lite was applied at the onset of radiation-induced erythema in two studies and after the development of moist desquamation in one study. Meta-analysis of RISRAS scores from two studies showed significant improvement with Mepilex Lite: combined score mean difference -0.98 (95% CI, -1.41 to -0.56, p < 0.01; I

conclusionMepilex Lite dressings may help reduce the severity and duration of radiation dermatitis and may improve patient comfort. However, due to significant heterogeneity among studies and variation in outcome reporting, further studies are required to confirm these findings.

Indexed as

BandagesRadiodermatitisHumansQuality of LifeRandomized Controlled Trials as TopicSeverity of Illness IndexSiliconesWound HealingmepitelSiliconesMepilex LiteMeta-analysisRadiation dermatitisRandomized controlled trials

Identifiers

PMID42257988

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.