Evidence map›Paper›PMID 42257913›Full record

ArticleJournal of molecular histology2026

The possible therapeutic effect of platelet-rich plasma versus its derived exosomes in a hydrogen peroxide-induced depigmentation model in adult guinea pigs: a histological study.

Ayat Fadel Hussieny, Seham Kamel Abounasef, Ghada Galal Hamam, Eman Ali Negm

Abstract read
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In one paragraph

Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ayat Fadel HussienyHistology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. ayatfadel@med.asu.edu.eg.
Seham Kamel AbounasefHistology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ghada Galal HamamHistology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Eman Ali NegmHistology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitiligo is a pigmentary disorder characterized by the loss of functional melanocytes, leading to depigmented skin patches and significant psychological burden. Platelet-rich plasma (PRP) and its derived exosomes have recently gained attention as potential regenerative therapies due to their immunomodulatory and antioxidant effects.To evaluate the therapeutic effects of platelet-rich plasma (PRP) versus its derived exosomes in a hydrogen peroxide-induced depigmentation model in guinea pigs.Forty-two adult male guinea pigs were divided into control, depigmentation, PRP-treated, and PRP-exosome-treated groups. Depigmentation was induced using topical H

Indexed as

ExosomesHydrogen PeroxidePlatelet-Rich PlasmaSkin PigmentationVitiligoAnimalsDisease Models, AnimalGuinea PigsMaleMelaninsMelanocytesOxidative StressHydrogen PeroxideMelaninscatalaseCD3DepigmentationExosomesFontana–Masson silver stainMelan APRP

Identifiers

PMID42257913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.