Evidence map›Paper›PMID 42257911›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Acute symptomatic seizures after accidental intrathecal lidocaine administration: A case series.

Luciano Pellegrino, Giulia Bruschi, Rossana Ragone, Dario Seppi, Silvia Favaretto, Maurizio Corbetta, Filippo Dainese

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luciano PellegrinoDepartment of Neuroscience, University of Padua, Padua, Italy. luciano.pellegrino@aulss6.veneto.it.ORCID http://orcid.org/0009-0005-5350-5031
Giulia BruschiDepartment of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
Rossana RagoneDepartment of Neuroscience, University of Padua, Padua, Italy.
Dario SeppiClinical Neurophysiology Unit, Neurology Clinic, Azienda Ospedale Università di Padova, Padua, Italy.
Silvia FavarettoClinical Neurophysiology Unit, Neurology Clinic, Azienda Ospedale Università di Padova, Padua, Italy.
Maurizio CorbettaDepartment of Neuroscience, University of Padua, Padua, Italy.
Filippo DaineseClinical Neurophysiology Unit, Neurology Clinic, Azienda Ospedale Università di Padova, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLidocaine (LA) is a widely used local anaesthetic and analgesic, and a potential therapeutic option for status epilepticus; however, due to its neurotoxicity, it also carries an associated risk of inducing life-threatening seizures and other neurological conditions. The semiology and the treatment of these provoked seizures remain poorly understood.

objectivesTo better understand the seizure-related behaviour, clinical presentation and electroencephalographic patterns associated to lidocaine-induced seizures.

methodsIn this paper we describe three cases of inadvertent intrathecal LA administration for chronic lumbar pain focusing on clinical presentation, laboratory and neuroimaging findings.

conclusionsAcute symptomatic seizures may represent an adverse reaction to intrathecal lidocaine administration and may present with TNS and alteration of consciousness, leading to status epilepticus. A prompt initiation of antiseizure therapy should be considered to ensure the best outcome.

Indexed as

Anesthetics, LocalLidocaineSeizuresAgedElectroencephalographyFemaleHumansInjections, SpinalLow Back PainMaleMiddle AgedAnesthetics, LocalLidocaineAdverse eventEEGLidocaineParavertebral injectionStatus epilepticusSystemic toxicity

Identifiers

PMID42257911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.