Evidence map›Paper›PMID 42257780›Full record

ArticleBreast cancer research and treatment2026

Age-related differences in psychological distress and persistent postsurgical pain after surgery for management of non-invasive breast lesions.

Jenna M Wilson, Shoshana M Rosenberg, Kerri-Anne Crowell, Thomas Lynch, Deborah Collyar, Desiree Basila, Elizabeth S Frank, Sonja Darai, Terry Hyslop, Carmine Valenza and 4 more

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Article in Breast cancer research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

14 authors.

Jenna M WilsonBrigham and Women's Hospital, Harvard Medical School, 45 Francis St., Boston, MA, 02115, USA. jwilson47@mgb.org.
Shoshana M RosenbergDana-Farber Cancer Institute, Boston, MA, USA.
Kerri-Anne CrowellDuke University, Durham, NC, USA.
Thomas LynchDuke University, Durham, NC, USA.
Deborah CollyarPatient Leadership Team, PORTAL Study, Boston, USA.
Desiree BasilaPatient Leadership Team, PORTAL Study, Boston, USA.
Elizabeth S FrankDana-Farber Cancer Institute, Boston, MA, USA.
Sonja DaraiDana-Farber Cancer Institute, Boston, MA, USA.
Terry HyslopDuke University, Durham, NC, USA.
Carmine ValenzaDana-Farber Cancer Institute, Boston, MA, USA.
Alastair M ThompsonBaylor College of Medicine, Houston, TX, USA.
Ann H PartridgeDana-Farber Cancer Institute, Boston, MA, USA.
E Shelley HwangDuke University, Durham, NC, USA.
Kristin L SchreiberStandford University, Palo Alto, CA, USA.

Funding

Patient-Centered Outcomes Research Institute CER-1503-29572
6 · The paper itself

Abstract

purposeYounger women who have undergone surgery for non-invasive breast lesions may experience heightened psychological distress and persistent postsurgical pain (PPSP). We investigated whether younger age was associated with worse PPSP outcomes, and whether depression or anxiety contributed to these associations.

methodsThis was a secondary analysis of a cross-sectional survey of women (N = 821; Mean age = 60, range:26-88) who underwent surgical management of ductal carcinoma in situ (DCIS) or high-risk lesions (atypical ductal hyperplasia, atypical lobular hyperplasia, lobular carcinoma in situ). Participants completed assessments of surgical-site pain severity, frequency, and impact of pain on cognitive/emotional and physical functioning, as well as measures of depression and anxiety. Mediation analyses tested whether depression or anxiety contributed to associations between younger age and worse PPSP outcomes, controlling for relevant surgical and treatment factors.

resultsOverall, 15% of women reported clinically significant PPSP (≥ 3/10). Younger age was associated with higher rates of clinically significant PPSP, higher pain severity index (PSI) scores, greater impact of pain on cognitive/emotional functioning, and higher depression and anxiety (all p-values < 0.001). Mediation analyses indicated that depression, but not anxiety, partially contributed to the association between younger age and worse PPSP outcomes.

conclusionDepression contributed to the association of younger age with worse PPSP outcomes among women undergoing surgery for non-invasive breast lesions. These results underscore the importance of screening for PPSP and depression following surgery, particularly in younger women. Targeted psychological interventions may help improve long-term recovery in this vulnerable group.

Indexed as

Breast NeoplasmsPostoperative PainPsychological DistressAdultAgedAged, 80 and overAge FactorsAnxietyCross-Sectional StudiesDepressionFemaleHumansMastectomyMiddle AgedAgeBreast surgeryDepressionDuctal carcinoma in situHigh-risk lesionsPersistent postsurgical pain

Identifiers

PMID42257780

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.